Strategies for the Preparation of (1-Acetyloxyethylidene)-1,1-bisphosphonic Acid Derivatives

Abstract

The novel strategies for the synthesis of acetylated etidronic acid derivatives were investigated. (1-Acetyloxyethylidene)-1,1-bisphosphonic acid and its P,P′-dimethyl, trimethyl and tetramethyl esters were prepared in high 81-100% yields.

Key words

bisphosphonate - etidronate - partial esters - synthesis - prodrug

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