Literatur
- 1
Andersen-Ranberg K, Christensen K, Jeune B. et al .
Declining physical abilities with age: a cross-sectional study of older twins
and centenarians in Denmark.
Age and Ageing.
1999;
28
373-377
- 2
Berlett B S, Stadtman E R.
Protein oxidation in aging, disease and oxidative stress.
J Biol Chem.
1997;
272
20313-20316
- 3
Blackman M R, Sorkin J D, Munzer T. et al .
Growth hormone and sex steroid administration in healthy aged women and men:
a randomized controlled trial.
JAMA.
2000;
288
2282-2292
- 4
Cawthon R M, Smith K R, O’Brien E. et al .
Association between telomere length in blood and mortality in people aged 60
years or older.
Lancet.
2003;
361
393-395
- 5
Finch C E, Tanzi R E.
Genetics of aging.
Science.
1997;
278
407-411
- 6
Floyd R A.
Oxidative damage to behaviour during aging.
Science.
1991;
245
1597
- 7
Flurkey K, Papaconstantinou J, Harrison D E.
The Snell dwarf mutation Pit1 (dw) can increase life-span in mice.
Mech Ageing Dev.
2002;
123
121-130
- 8
Garasto S, Rose G, Derango F. et al .
The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals
another paradox in the oldest old subjects.
Ann Hum Genet.
2003;
67
54-62
- 9
Goldstein S, Murano S, Benes H. et al .
Studies on the molecular-genetic basis of replicative senescence in Werner syndrome
and normal fibroblasts.
Exp Gerontol.
1989;
24
461-468
- 10
Greider C W, Blackburn E H.
Identification of a specific telomere terminal transferase activity in Tetrahymena
extracts.
Cell.
1985;
43
405-413
- 11
Greider C W.
Telomeres and senescence: the history, the experiment, the future.
Curr Biol.
1998;
8
R178-R181
- 12
Harman D.
Aging: a theory based on free radicals and radiation chemistry.
J Gerontol.
1956;
11
298-300
- 13
Harman D.
The aging process.
Proc Natl Acad Sci U S A.
1981;
78
7124-7128
- 14
Hayflick L.
The limited in vitro lifetime of human diploid cell strains.
Exp Cell Res.
1965;
37
614-636
- 15
Herskind A M, McGue M, Holm N V. et al .
The heritability of human longevity: a population-based study of 2872 Danish
twin pairs born 1870 - 1900.
Hum Genet.
1996;
97
319-323
- 16
Jazwinski S M.
Longevity, genes and aging.
Science.
1996;
273
54-59
- 17 Kaeberlein M, McVey M, Guarente L. Using yeast to discover the fountain of
youth. Washington (DC): American Association for the Advancement of Science;
New Findings Perspectives In: Science of aging and knowledge enviroment;http//sageke.sciencemag.org/cgi/content/full/sageke;2001/1/pel
2001
- 18
Kang M K, Swee J, Kim R H. et al .
The telomeric length and heterogeneity decrease with age in normal human oral
keratinocytes.
Mech Ageing Dev.
2002;
123
585-592
- 19 Kannisto V. Development of Oldest-Old Mortality, 1950 - 1990: evidence from
28 developed countries. Odense:Univ. Press Odense Monographs on Population
Aging 1 1994
- 20
Lin Y J, Seroude L, Benzer S.
Extended life-span and stress resistance in the Drosophila mutant Methuselah.
Science.
1998;
282
943-946
- 21
Ljungquist B, Berg S, Lanke J. et al .
The effect of genetic factors for longevity: a comparison of identical and fraternal
twins in the Swedish Twin Registry.
J Gerontol A Biol Sci Med Sci.
1998;
53
M441-M446
- 22
Lithgow G J, Andersen J K.
The real Dorian Gray mouse.
Bioessays.
2000;
22
410-413
- 23
Masoro E J.
Dietary restriction and aging.
J Am Geriatr Soc.
1993;
41
994-999
- 24
McCall M R, Frei B.
Can antioxidant vitamins maternally reduce oxidative damage in humans?.
Free Radical Biol Med.
1999;
26
1034-1053
- 25
McCarter R, Masoro E J, Yu B P.
Does food restriction retard aging by reducing the metabolic rate?.
Am Physiol.
1985;
248
E488-E490
- 26
Meydani M.
Nutrition interventions in aging and age-associated disease.
Ann N Y Acad Sci.
2001;
928
226-235
- 27
Mitnitski A B, Graham J E, Mogilner A J. et al .
Frailty, fitness and late-life mortality in relation to chronological and biological
age.
BMC Geriatr.
2002;
2
1
- 28
Murakami S, Johnson T E.
A genetic pathway conferring life extension and resistance to UV stress in Caenorhadtitis
elegans.
Genetics.
1996;
143
1207-1218
- 29
Oeppen J, Vaupel J W.
Broken limits to life expectancy.
Science.
2002;
296
1029-1030
- 30
Olovnikov A M.
A theory of marginotomy:The incomplete copying of template margin in enzymic
synthesis of polynucleotides and biological significance of the phenomenon.
J Theor Biol.
1973;
41
181-190
- 31
Orr W C, Chen C N> L.
Aging and neural control of the GI tract: IV. Clinical and physiological aspects
of gastrointestinal motility and aging.
Am J Physiol Gastrointest Liver Physiol.
2002;
283
G1226-1231
- 32
Orr W C, Sohal R S.
Extension of life-span by overexpression of superoxide dismutase and catalase
in Drosophila melanogaster.
Science.
1994;
263
1128-1130
- 33
Ozawa T.
Genetic and functional changes in mitochondria associated with aging.
Physiol Rev.
1997;
77
425-464
- 34
Perls T, Levenson R, Regan M. et al .
What does it take to live 100?.
Mech Ageing Dev.
2002;
123
231-242
- 35
Puca A A, Daly M J, Brewster S J. et al .
A genome-wide scan for linkage to human exceptional longevity identifies a locus
on chromosome 4.
PNAS.
2001;
98
10505-10508
- 36
Rodriguez-Martinez M A, Izaguirre J, Ruiz-Torres A.
Oxidative detoxification capacity with aging and after the intake of peroxidised
oil years ago.
Horm Metab Res.
1991;
23
46-47
- 37
Roberts T W, Smith J R.
The proliferation potential of chick embryo fibroblasts: population doublings
vs. time culture.
Cell Biol Int Rep.
1980;
4
1057-1063
- 38
Rogina B, Reenan R A, Nilsen S P. et al .
Extendes life-span conferred by cotransporter gene mutations in Drosophila.
Science.
2000;
290
2137-2140
- 39
Rudman D, Feller A G, Nagraj H S. et al .
Effects of human growth hormone in men over 60 years old.
N Engl J Med.
1990;
323
1-6
- 40
Shay J W, Wright W E.
Hayflick, his limit and cellular aging.
Nature Rev Mol Cell Biol.
2000;
1
72-76
- 41
Sohal R S, Svensson I, Sohal B H. et al .
Superoxide anion radical production in different species.
Mech Ageing Dev.
1989;
49
129-135
- 42
Sohal R S, Weindruch R.
Oxidative stress, caloric restriction and aging.
Science.
1996;
273
59-63
- 43
Schachter F, Faure-Delanef L, Guenot F. et al .
Genetic associatios with human longevity and the ApoE and ACE loci.
Nat Genet.
1994;
6
29-32
- 44
Schneider E L, Mitsui Y.
The relationship between in vitro cellular aging and in vivo human age.
Proc Natl Acad Sci U S A.
1976;
73
3584-3588
- 45
Urquidi V, Tarin D, Goodison S.
Role of telomerase in cell senescence and oncogenesis.
Annu Rev Med.
2000;
51
65-79
- 46
Vaupel J W, Carey J R, Christensen K. et al .
Biodemographic trajectories of longevity.
Science.
1998;
20
855-860
- 47
Vaupel J W.
Inherited frailty and longevity.
Demography.
1988;
25
277-287
- 48 Vaupel J W, Jeune B. Exceptional Longevity: From Prehistory to the present. Odense:
Univ. Press 1996: 109
- 49
Wallace D C.
Mitochondrial genetics: a paradigm for aging and degenerative diseases?.
Science.
1992;
256
628-623
- 50
Weindruch R, Walford R L.
Dietary restriction in mice beginning at 1 year of age: effect of life-span
and spontaneous cancer incidence.
Science.
1982;
215
1415-1418
Prof. Dr. med. Stefan Schreiber
Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Allgemeine Innere
Medizin, 1.Medizinische Klinik
Schittenhelmstraße 12
24114 Kiel
