Zusammenfassung
Die Perfusions-MRT hat sich in den vergangenen Jahren in der klinischen Routine etabliert.
Sie ermöglicht es, Veränderungen des kapillären Netzwerks und des kapillären Blutflusses
zu beurteilen. Daher ist diese Methode für viele neuroradiologische Fragestellungen
interessant. In diesem Beitrag wird die Methodik ausführlich dargestellt, wobei dem
Leser vor allem die Aspekte vermittelt werden sollen, die bei der praktischen Durchführung
von Messung und Auswertung zu beachten sind. Im zweiten Teil werden die wesentlichen
Anwendungsgebiete der Perfusions-MRT dargestellt und es wird beschrieben, wie sich
die aus der Perfusions-MRT berechneten Parameter bei unterschiedlichen Erkrankungen
verändern. Dabei werden auch Hinweise auf mögliche Fallstricke gegeben, die für Fehldiagnosen
verantwortlich sein können.
Summary
Perfusion MRI has recently been established in clinical routine. It allows monitoring
pathologic changes of the capillary network and the capillary blood flow. Therefore,
perfusion MRI can help to improve the diagnosis in a variety of cerebral diseases.
This paper describes the method, focussing on practical aspects that need to be considered
when performing data acquisition and postprocessing. The second part of the paper
presents the main areas of application and describes how different diseases change
the parameters calculated from perfusion MRI. Pitfalls as potential source of a false
diagnosis are discussed.
Key words
Magnetic resonance imaging - perfusion - contrast agent - cerebral ischemia - tumors
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Prof. Dr. rer. nat. Sabine Heiland
Sektion Experimentelle Neuroradiologie, Universitätsklinikum Heidelberg
Im Neuenheimer Feld 400 · 69120 Heidelberg
Phone: +49(0)6221 56-7566
Fax: +49(0)6221 56-4673
Email: sabine_heiland@med.uni-heidelberg.de
