Synthesis of Azaspiro[4.4]nonanes as Key Structures of Several Bioactive Natural Products

Serry A. A. El Bialy; Holger Braun; Lutz F. Tietze

doi:10.1055/s-2004-831198

REVIEW

Synthesis of Azaspiro[4.4]nonanes as Key Structures of Several Bioactive Natural Products

Serry A. A. El Bialy, Holger Braun, Lutz F. Tietze*
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstraße 2, 37077 Göttingen, Germany
Fax: +49(551)399476; e-Mail: ltietze@gwdg.de;

Abstract

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Abstract

This review presents the recent progress in the synthesis of azaspiro[4.4]nonane focussing on key steps. The syntheses of both racemic and non-racemic compounds are described.

1 Introduction

2 Formation of a Cyclopentane Ring onto a Pre-existing Pyrrolidine Derivative

3 Formation of a Pyrrolidine Ring onto a Pre-existing Cyclopentane Derivative

4 Conclusions

Key Words

alkaloids - azo compounds - heterocycles - natural products - spiro compounds - transition metal catalysis

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