An efficient procedure is established to synthesize 3′,5′-dithio-2′-deoxyadenosine
starting from 2′-deoxyadenosine in five steps in 33% overall yield. In this procedure,
the key intermediate 9 was synthesized by twice SN2 reactions with twice 3′-configuration inversions and then it was deprotected to
title compound by removing three acyl groups in one pot.
3′,5′-dithio-2′-deoxynucleoside - 3′,5′-dithio-2′-deoxyadenosine - disulfur-backboned
nucleic acid - configuration inversions - synthesis
