First Total Synthesis of Caminoside A, an Antimicrobial Glycolipid from Sponge

Jiansong Sun; Xiuwen Han; Biao Yu

doi:10.1055/s-2004-837221

LETTER

First Total Synthesis of Caminoside A, an Antimicrobial Glycolipid from Sponge

Jiansong Sun^a, Xiuwen Han^a, Biao Yu*^b
^a State Key Laboratory of Catalyst, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
^b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China
e-Mail: byu@mail.sioc.ac.cn;

Abstract

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Abstract

Caminoside A, a novel antimicrobial tetrasaccharide glycolipid from the marine sponge Caminus sphaeroconia, which represents the first bacterial type III secretion inhibitor, is synthesized in a total of 57 steps starting from d-glucose, d-galactose, l-rhamnose, and 9-decenal.

Key words

caminoside A - d-glucose - d-galactose

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References

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