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Facial Plast Surg 2004; 20(2): 129-134
11 January 2005 (online)
Soft tissue replacement using a filler as a temporary scaffold to encourage revascularization and tissue in growth is an exciting concept. Sheets of acellular human dermal matrix, called Alloderm (Lifecell Corp, Branchburg, NJ), have been shown to do just that. When implanted into a patient, tissue growth and revascularization have both been observed.  The company manufactures a micronized or injectable form called Cymetra. This article reviews the manufacturing, tissue interaction, clinical applications, and anticipated clinical results.
Acellular dermal matrix - Cymetra
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- 2 Kraut J, Eckhardt A, Patton M, Antoniades K, Haith L, Shotwell B. Combined simultaneous application of cultured epithelial autografts and Alloderm. Wounds. 1995; 7 137-142
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- 4 Sclafani A, Romo T, Jacono A. Rejuvenation of the aging lip with an injectable acellular dermal graft (Cymetra). Arch Facial Plast Surg 2002 4: 252-257
- 5 Sclafani A, Romo T, Jacono A. Evaluation of acellular dermal graft in sheet (Alloderm) and injectable (micronized Alloderm) forms for soft tissue augmentation. Arch Facial Plast Surg 2000 2: 130-136
Brian P MaloneyM.D. F.A.C.S.
5505 Peachtree Dunwoody Road
Suite 630, Atlanta, GA 30342