Zusammenfassung
Das hepatozelluläre Karzinom (HCC) ist weltweit einer der häufigsten malignen Tumoren
mit steigender Inzidenz auch in westlichen Ländern. Das HCC wird typischerweise erst
relativ spät im Verlauf diagnostiziert und bis auf wenige Ausnahmen ist die Prognose
ungünstig. Potenziell kurative Therapieansätze sind die Tumorresektion und in ausgewählten
Fällen die Lebertransplantation. Diese chirurgischen Verfahren kommen aber aufgrund
des Tumorstadiums oder der Leberfunktion für einen Großteil der Patienten nicht infrage.
Weitere nichtchirurgische Therapieverfahren wie Radiofrequenzthermo- und Kryoablation,
Alkohol- oder Säureinjektionen, transarterielle Chemoembolisationen, Strahlentherapie
und systemische Chemotherapie können einzeln oder in Kombination in den verschiedenen
Stadien der Erkrankung eingesetzt werden, um eine Verlängerung des (rezidivfreien)
Überlebens und in wenigen Fällen auch eine Heilung zu erzielen.
Abstract
Hepatocellular carcinoma is one of the most common cancers worldwide. The incidence
of this disease is also increasing in the Western world. Typically, HCC is diagnosed
when patients have already reached an advanced stage of the disease and the prognosis
is poor. Potentially curative treatment options include surgical resection or liver
transplantation and can be offered to patients with adequate liver function and tumour
stage. Other non-surgical treatment options such as radiofrequency ablation, cryoablation,
ethanol or acetic acid injection, transarteriel chemoembolisation radiation therapy
and systemic chemotherapy can be offered either alone or in combination to selected
groups of patients. These treatments can improve (tumour-free) survival and in a few
cases even cure the patient.
Schlüsselwörter
Leber - Chemotherapie - Krebs
Key words
Liver - chemotherapy - cancer
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PD Dr. Tim F. Greten
Abt. Gastroenterologie, Hepatologie und Endoskrinologie, Medizinische Hochschule Hannover
Carl-Neuberg-Str. 1
30625 Hannover
eMail: greten.tim@mh-hannover.de
