Horm Metab Res 2005; 37(1): 32-35
DOI: 10.1055/s-2005-861029
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Dietary Fructose on Liver Steatosis in Overfed Mule Ducks

S.  Davail1 , N.  Rideau2 , M.  D.  Bernadet3 , J.  M.  André1 , G.  Guy3 , R.  Hoo-Paris1
  • 1Laboratoire de Biologie et Nutrition Appliquée, IUT des Pays de l'Adour, Mont de Marsan, France
  • 2Station de recherches avicoles, INRA de Tours-Nouzilly, Nouzilly, France
  • 3Station Expérimentale des Palmipèdes à Foie Gras, INRA, Artiguères, Benquet, France
Further Information

Publication History

Received 3 March 2004

Accepted after Revision 31 August 2004

Publication Date:
28 January 2005 (online)

Abstract

Overfeeding of some waterfowl species results in obesity, which is mainly characterized by a dramatic hepatic steatosis induced by strong accumulation of lipids synthesized from dietary glucose in the liver. In mammals, fructose is known to be able to raise plasma triacylglycerol concentrations significantly; consequently, this may induce obesity. The aim of this study was to assess the effect of partial replacement of dietary glucose provided by corn starch with fructose on metabolism and fatty liver production in the Mule ducks. On the basis of 9.5 kg maize (132,920 kJ) given twice a day for 14 days, a supplementation of 9,800 kJ was provided in form of glucose, sucrose or high fructose corn syrup (HFCS: 50 % glucose, 42 % fructose and 8 % other saccharides). Fatty liver weight in ducks fed with glucose supplementation was 499 ± 21 g. Sucrose or HFCS supplementation brought about a significant increase in liver weight (+ 18.7 % and + 16.3 % vs. glucose supplementation respectively, p < 0.05). These results suggest that the dietary fructose favors the liver steatosis by increasing hepatic lipogenesis. Postprandial plasma insulin concentrations were similar in ducks fed diets with or without fructose, suggesting that the effect of fructose on liver steatosis is not mediated by insulin.

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R. Hoo-Paris

Laboratoire de Nutrition et Biologie Appliquée IUT de Mont de Marsan

371 rue du ruisseau BP 201 · 40004 Mont de Marsan Cedex · France

Phone: +33 (5) 58513700

Email: robert.hoo-paris@univ-pau.fr

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