Horm Metab Res 2005; 37(2): 111-117
DOI: 10.1055/s-2005-861160
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Nutrient-stimulated GLP-1 Release in Normal-weight Men and Women

T.  C.  M.  Adam1 , M.  S.  Westerterp-Plantenga1
  • 1Department of Human Biology, Maastricht University, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht, The Netherlands
Further Information

Publication History

Received 15 June 2004

Accepted after revision 7 September 2004

Publication Date:
21 March 2005 (online)


The aim of the present study was to investigate the effect of a monosaccharide/fiber preload (galactose/guar gum) in combination with a standard breakfast (GG) on plasma GLP-1, insulin, glucose, free fatty acid concentrations, and appetite ratings (satiety, hunger, fullness and desire to eat) in 30 normal-weight subjects. GG was compared to water in combination with the standard breakfast (W). We also tested for differences in GLP-1 release in the described conditions between genders. In women, postprandial plasma GLP-1 concentrations after GG were significantly increased compared to W (p < 0.05). The area under the curve (AUC) for ΔGLP-1 after GG was related to body fat (%BF) in women (r = 0.48; p = 0.02), but not in men. The rise in plasma insulin was delayed, and plasma glucose concentration was blunted after GG. Δsatiety was significantly related to ΔGLP-1 (W). In conclusion, galactose with guar gum increased and extended the GLP-1 release due to breakfast in women, but not in men. This may be partly explained by %BF, which is higher in women than in men since GLP-1 release appears to be related to %BF.


T. C. M. Adam

Department of Human Biology, Maastricht University

P.O. Box 616 · 6200 MD Maastricht · The Netherlands

Phone: +31 (43) 3882111

Fax: +31 (43) 3670976

Email: T.Adam@hb.unimaas.nl