Horm Metab Res 2005; 37(2): 118-122
DOI: 10.1055/s-2005-861161
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Spontaneous Prolactin Secretion in Growth Hormone-deficient Children

T.  M.  K.  Völkl1 , S.  Haas1 , H.  G.  Dörr1
  • 1Division of Pediatric Endocrinology, Hospital for Children and Adolescents, University of Erlangen-Nuremberg, Germany
Parts of this study have been presented at the 47th annual meeting of the German Endocrine Society (DGE) in Cologne, Germany
Further Information

Publication History

Received 3 June 2004

Accepted after revision 10 August 2004

Publication Date:
21 March 2005 (online)

Abstract

Objective: To establish the spontaneous nocturnal prolactin (PRL) release in relation to growth hormone (GH)-deficient children and idiopathic short-stature children (ISS). Methods: A total of 32 prepubertal children (11 girls, 21 boys) aged between 3 and 12 years were studied retrospectively and sorted according to diagnosis: idiopathic GH deficiency (GHD, n = 9), neurosecretory deficiency of GH secretion (NSD, n = 10) and ISS (n = 13). Nocturnal spontaneous hormone secretion was studied by intermittent venous sampling. Secretion profiles and copulsatility were analyzed using Pulsar and AnCoPuls software. Results: (median, range in μg/l): Children with GHD and NSD had significantly lower GH and area-under-the-curve (AUC) levels than normal children (p < 0.001), whereas ISS children showed normal values. In contrast, prolactin levels were significantly higher (p < 0. 05) in children with GHD and NSD (11.1, 4.9 - 13.0 and 10.3, 8. 8 - 19. 6, respectively) compared to the ISS children (8.0, 4.9 - 13.0). In addition, prolactin AUC and peak height were higher (p < 0.05) in GH-deficient patients, whereas all other secretion parameters were the same. Correlation and copulsatility analysis revealed no evidence for a direct relation between PRL and GH secretion. Conclusions: PRL secretion is significantly higher in children with GHD and NSD compared to ISS children but PRL and GH show no copulsatile secretion pattern.

References

Prof. Helmuth G. Dörr, M. D.

Division of Pediatric Endocrinology, Hospital for Children and Adolescents, Friedrich-Alexander-University of Erlangen-Nuremberg

Loschgestrasse 15 · 91054 Erlangen · Germany

Phone: +49 (9131) 8533732

Fax: +49 (9131) 8533713

Email: hgdoerr@kinder.imed.uni-erlangen.de