Behandlung der Innenohrschwerhörigkeit bei akuter viraler Otitis media mittels intratympanaler Injektion von Dexamethason und Hyaluronsäure im Vergleich zur rheologischen Infusionstherapie

M. Stenner; P. Jecker; H. Gouveris; W. Mann

doi:10.1055/s-2005-870274

Laryngo-Rhino-Otologie, Table of Contents

Laryngorhinootologie 2006; 85(1): 32-37
DOI: 10.1055/s-2005-870274

Otologie

Behandlung der Innenohrschwerhörigkeit bei akuter viraler Otitis media mittels intratympanaler Injektion von Dexamethason und Hyaluronsäure im Vergleich zur rheologischen Infusionstherapie

Treatment of Sensorineural Hearing Loss in Acute Viral Otitis Media with Intratympanic Dexamethasone and Hyaluronic Acid in Comparison with Intravenous TherapyM. Stenner¹ , P. Jecker¹ , H. Gouveris¹ , W. Mann¹

¹ Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde der Johannes-Gutenberg-Universität Mainz (Direktor: Prof. Dr. Dr. h. c. mult. W. J. Mann)

Statistische Beratung durch das Institut für Medizinische Biometrie, Epidemiologie und Informatik (IMBEI) der Johannes-Gutenberg-Universität Mainz.Auszugsweise vorgetragen auf der 88. Jahrestagung der Vereinigung Südwestdeutscher Hals-Nasen-Ohrenärzte, September 2004 in Pforzheim.

Abstract

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References

Literatur

1 Francois M. New views on the pathogenesis of acute otitis media and its complications. Clin Microbiol Infect. 1997; 3 S5-S12
2 Tarlow M. Otitis media: pathogenesis and medical sequelae. Ear Nose Throat J. 1998; 77 3-6
3 Harada T, Yamasoba T, Yagi M. Sensorineural hearing loss associated with otitis media with effusion. ORL J Otorhinolaryngol Relat Spec. 1992; 54 61-65
4 Münker G. Inner ear hearing loss in acute and chronic otitis media. Adv Otorhinolaryngol. 1981; 27 138-143
5 Cook R D, Postma D S, Brinson G M, Prazma J, Pillsbury H C. Cytotoxic changes in hair cells secondary to pneumococcal middle-ear infection. J Otolaryngol. 1999; 28 325-331
6 Michel O, Jahns T, Joos-Enneking M, Neugebauer P, Streppel M, Stennert E. Das antiphlogistisch-rheologische Infusionsschema nach Stennert in der Behandlung von kochleovestibulären Störungen. HNO. 2000; 48 182-188
7 Ziegler E A, Hohlweg-Majert B, Maurer J, Mann W J. Epidemiologische Daten des Hörsturzes - eine retrospektive Studie über drei Jahre. Laryngo-Rhino-Otol. 2003; 82 4-8
8 Chandrasekhar S S, Rubinstein R Y, Kwartler J A, Glatz M, Connelly P E, Huang E, Baredes S. Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents. Otolaryngol Head Neck Surg. 2000; 122 521-528
9 Chandrasekhar S S. Intratympanic dexamethasone for sudden sensorineural hearing loss: clinical and laboratory evaluation. Otol Neurotol. 2001; 22 18-23
10 Arriaga M A, Goldmann S. Hearing results of intratympanic steroid treatment of endolymphatic hydrops. Laryngoscope. 1998; 108 1682-1685
11 Shirwany N A, Seidmann M D, Tang W. Effect of transtympanic injection of steroids on cochlear blood flow, auditory sensitivity, and histology in the guinea pig. Am J Otol. 1998; 19 230-235
12 Silverstein H, Isaacson J E, Olds M J, Rowan P T, Rosenberg S. Dexamethasone inner ear perfusion for the treatment of Menière’s disease: a prospective, randomized, double-blind, crossover trial. Am J Otol. 1998; 19 196-201
13 Parnes L S, Sun A H, Freeman D J. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope. 1999; 109 1-17
14 Parving A, Ostri B. On objective criteria for hearing impairment and hearing disability. Scand Audiol. 1983; 12 165-169
15 Sha S, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res. 2001; 155 1-8
16 Claes J, van de Heyning P H. A review of medical treatment for Menière’s disease. Acta Otolaryngol. 2000; 544 34-39
17 Ulfendahl M, Scarfone E, Flock A, Le Calvez S, Conradi P. Perilymphatic fluid compartments and intercellular spaces in the inner ear and the organ of Corti. Neuroimage. 2000; 12 307-313
18 Roland J T, Magardino T M, Go J T, Hillmann D E. Effects of glycerin, hyaluronic acid, and hydroxypropyl methylcellulose on the spiral ganglion of the guinea pig cochlea. Ann Otol Rhinol Laryngol. 1995; 166 64-68
19 Selivanova O, Maurer J, Ecke U, Mann W J. Elektrophysiologische Untersuchungen zum Einsatz von Streptolysin O und Natrium-Hyaluronat zur Permeabilitätsmodulation der Membran des runden Fensters beim Meerschweinchen. Laryngo-Rhino-Otol. 2003; 82 235-239
20 Gouveris H, Selivanova O, Mann W. Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensorineural hearing loss after failure of intravenous steroid and vasoactive therapy. Eur Arch Otorhinolaryngol. 2004; in Druck
21 Engel F, Blatz R, Kellner J, Palmer M, Weller U, Bhakdi S. Breakdown of the round window membrane permeability barrier evoked by streptolysin O: possible etiologic role in development of sensorineural hearing loss in acute otitis media. Infect Immun. 1995; 63 1305-1310
22 Engel F, Blatz R, Schliebs R, Palmer M, Bhakdi S. Bacterial cytolysin perturbs round window membrane permeability barrier in vivo: possible cause of sensorineural hearing loss in acute otitis media. Infect Immun. 1998; 66 343-346

Dr. med. Markus Stenner

Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde der Johannes-Gutenberg-Universität Mainz

Langenbeckstraße 1 · 55101 Mainz

Email: stenner@hno.klinik.uni-mainz.de