Soluble TNF Receptors and Albuminuria in Non-obese Japanese Type 2 Diabetic Patients

Abstract

The aim of this study was to investigate the relationships between albuminuria and tumor necrosis factor (TNF)-α or soluble TNF receptors (sTNF-R1, sTNF-R2) in eighty-eight non-obese Japanese type 2 diabetic patients stratified into two groups according to albuminuria status-microalbuminuria or normoalbuminuria. Patients with microalbuminuria were older and had significantly higher concentrations of sTNF-R1 and sTNF-R2 than those with normoalbuminuria. There was, however, no significant difference in sex, diabetes duration, smoking, BMI, systolic and diastolic blood pressure, HbA_1c, serum creatinine, and lipid profile between the two groups. Although serum TNF-α was positively correlated to serum sTNF-R1 and sTNF-R2, serum TNF-α level did not differ with respect to albuminuria. Univariate regression analysis showed that urinary albumin concentration was positively correlated to age (r = 0.380, p < 0.001), serum creatinine (r = 0.214, p < 0.05) and concentrations of sTNF-R1 (r = 0.364, p < 0.001) and sTNF-R2 (r = 0.342, p < 0.005). Other variables, including TNF-α, were not associated with albuminuria. Multiple regression analyses showed that urinary albumin concentration was independently predicted by the level of sTNF-R1 (F = 32.1), which explained 26.3 % of the variability of urinary albumin concentration. From these results, it can be concluded that serum soluble TNF receptor is an important independent factor associated with albuminuria in non-obese Japanese type 2 diabetic patients.

Key words

sTNF receptors - TNF-alpha - Albuminuria - Diabetes

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