Total Synthesis of (+)-Pseudodistomin D
B. M. Trost*, D. R. Fandrick
Stanford University, USA
21 September 2005 (online)
The alkaloid Pseudodistomin D was isolated from the ascidian Pseudodistomina megalarva along with pseudodistomins B, C, E and F. The biological activities of these compounds include calmodulin antagonist activity and cytotoxicity against several cancer cell lines. This first total synthesis confirms the absolute stereochemistry of the natural product.