A new chemical method is described for the preparation of aryl or thienyl zinc intermediates
from their corresponding aromatic or thienyl chlorides in a mixture of acetonitrile-pyridine,
using cobalt catalysis. This procedure allows for the synthesis of a variety of functionalized
arylzinc species from reactive arylchlorides or chlorothiophenes in good to excellent
yields. Some of these arylzinc compounds have been coupled with aromatic bromides
using palladium catalysis.
cobalt halide - catalysis - zinc - thiophenes - aromatic chlorides