Facial plast Surg 2005; 21(2): 145-153
DOI: 10.1055/s-2005-872416
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001 USA.

Assessment of the Efficacy of Nonablative Long-Pulsed 1064-nm Nd:YAG Laser Treatment of Wrinkles Compared at 2, 4, and 6 Months

M. A. Trelles1 , X. Álvarez1 , M. J. Martín-Vázquez2 , O. Trelles2 , M. Velez1 , J. L. Levy3 , I. Allones1
  • 1Instituto Médico Vilafortuny /Antoni De Gimbernat Foundation, Cambrils, Spain
  • 2Computer Architecture Department, University of Málaga, Málaga, Spain
  • 3Centre Laser Dermatologique, Marseille, France
Further Information

Publication History

Publication Date:
28 July 2005 (online)


Rhytides represent an aesthetic problem for a large percentage of the population. Many methods, both noninvasive and invasive, have been used for the treatment of wrinkles. Recently, the long-pulsed 1064-nm Nd:YAG laser has been shown to enhance dermal collagen synthesis without damaging the epidermis. The purpose of this preliminary study is to evaluate the use of the long-pulsed Nd:YAG laser in the nonablative treatment of periocular and perioral wrinkles. Ten patients with facial wrinkles were treated with the long-pulsed 1064-nm Nd:YAG laser, at a spot size of 5 mm in diameter, energy density of 13 J/cm2, exposure time per pulse of 300 microseconds, and a repetition rate of 7 Hz. All patients had a total of three treatments, once every 2 weeks. Subjective (patient satisfaction index [SI]) and objective (both physician- and computer program-based clinical index [CI]) assessments were performed before the first and third treatment sessions, and at 2, 4, and 6 months after the last treatment. At 6 months after the final treatment session, the patients' subjective SI was maintained at 40%, and had peaked at 50% 2 months after the final session. Physician assessment showed a CI of 40% at the 6-month assessment point and the computer program showed a 50% CI. The greatest level of effect with long-pulsed Nd:YAG laser nonablative skin rejuvenation for facial wrinkles was seen 2 months after the final treatment. Effects were still visible at the 6-month period, but showed a tendency to decrease. Maintenance treatments are required to achieve good patient satisfaction.