Exp Clin Endocrinol Diabetes 2006; 114(1): 31-34
DOI: 10.1055/s-2005-873014
Case Report

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Diabetes Insipidus Due to Herpes Encephalitis in a Patient with Diffuse Large Cell Lymphoma. A Case Report

K. Scheinpflug1 , E. Schalk1 , K. Reschke2 , A. Franke1 , M. Mohren1
  • 1Department of Hematology and Oncology, Otto-von-Guericke-University, Magdeburg, Germany
  • 2Department of Endocrinology and Metabolism, Otto-von-Guericke-University, Magdeburg, Germany
Further Information

Publication History

Received: April 28, 2005 First decision: June 5, 2005

Accepted: October 28, 2005

Publication Date:
01 February 2006 (online)

Abstract

The major causes of central diabetes insipidus are neoplastic or infiltrative lesions of the hypothalamus or pituitary, severe head injuries and pituitary or hypothalamic surgery. Central diabetes insipidus caused by viral infections has been rarely reported in immunosuppressed patients, such as those with acquired immunodeficiency syndrome or Cushing's syndrome. We report the case of a 48-year-old woman suffering from diffuse large cell lymphoma, who developed hypotonic polyuria, hypernatriaemia and somnolence after the first course of chemotherapy with CHOEP and rituximab. Diabetes insipidus was diagnosed by low urine osmolarity and an undetectable vasopressin concentration. MRI revealed no pituitary abnormalities but encephalitis, and lumbar punction confirmed herpes zoster infection. To the best of our knowledge this is the first description of central diabetes insipidus in a lymphoma patient caused by an opportunistic CNS-infection.

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Dr. Katrin Scheinpflug

Department of Hematology and Oncology
Otto-von-Guericke-University

Leipziger Str. 44

39120 Magdeburg

Germany

Phone: + 49(0)3916713271

Fax: + 49 (0) 39 16 71 32 67

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