Exp Clin Endocrinol Diabetes 2006; 114(4): 160-167
DOI: 10.1055/s-2006-924081

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Postprandial Mononuclear NF-κB Activation is Independent of the AGE-content of a Single Meal

S. Schiekofer1 , 5 , S. Franke,2 , M. Andrassy1 , 6 , J. Chen,1 , 7 , G. Rudofsky1 , J. G. Schneider,1 , M. von Eynatten1 , T. Wendt,1 , M. Morcos1 , R. Kientsch-Engel,3 , G. Stein2 , E. Schleicher,4 , P. P. Nawroth1 , A. Bierhaus1
  • 1Department of Medicine I, University of Heidelberg, Heidelberg, Germany
  • 2Department of Medicine IV, University of Jena, Jena, Germany
  • 3Roche Diagnostics GmbH, Penzberg, Germany
  • 4Department of Medicine IV, University of Tübingen, Tübingen, Germany
  • 5Department of Medicine I, University of Ulm, Ulm, Germany
  • 6Department of Medicine III, University of Heidelberg, Heidelberg, Germany
  • 7Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Further Information

Publication History

Received: December 9, 2005 First decision: January 24, 2006

Accepted: February 10, 2006

Publication Date:
17 May 2006 (online)


ABTS 2.2-azino-di-[3-ethylbenzthiazoline sulfonate]diammonium salt

AGE's advanced glycation endproducts

CML Nε-(carboxymethyl)lysine

ELISA enzyme-linked immunoabsorbant assay

EMSA electrophoretic mobility shift assay

G-casein glucose casein

NF-κB nuclear factor-kappa B

pBMC peripheral blood mononuclear cells

RAGE receptor for AGE

ROS reactive oxygen species

S-casein sorbitol casein

SD standard deviation

TBE tris-borate-EDTA

TBS tris-buffered saline


PhD Angelika Bierhaus

Department of Medicine I
University of Heidelberg

Im Neuenheimer Feld 410

69120 Heidelberg


Phone: 0049(0)6221-56-4752

Fax: 00 49 (0) 62 21-56-47 54

Email: angelika_bierhaus@med.uni-heidelberg.de