Exp Clin Endocrinol Diabetes 2006; 114(4): 160-167
DOI: 10.1055/s-2006-924081
Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Postprandial Mononuclear NF-κB Activation is Independent of the AGE-content of a Single Meal

S. Schiekofer1 , 5 , S. Franke,2 , M. Andrassy1 , 6 , J. Chen,1 , 7 , G. Rudofsky1 , J. G. Schneider,1 , M. von Eynatten1 , T. Wendt,1 , M. Morcos1 , R. Kientsch-Engel,3 , G. Stein2 , E. Schleicher,4 , P. P. Nawroth1 , A. Bierhaus1
  • 1Department of Medicine I, University of Heidelberg, Heidelberg, Germany
  • 2Department of Medicine IV, University of Jena, Jena, Germany
  • 3Roche Diagnostics GmbH, Penzberg, Germany
  • 4Department of Medicine IV, University of Tübingen, Tübingen, Germany
  • 5Department of Medicine I, University of Ulm, Ulm, Germany
  • 6Department of Medicine III, University of Heidelberg, Heidelberg, Germany
  • 7Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Weitere Informationen

Publikationsverlauf

Received: December 9, 2005 First decision: January 24, 2006

Accepted: February 10, 2006

Publikationsdatum:
17. Mai 2006 (online)

Abbreviations

ABTS 2.2-azino-di-[3-ethylbenzthiazoline sulfonate]diammonium salt

AGE's advanced glycation endproducts

CML Nε-(carboxymethyl)lysine

ELISA enzyme-linked immunoabsorbant assay

EMSA electrophoretic mobility shift assay

G-casein glucose casein

NF-κB nuclear factor-kappa B

pBMC peripheral blood mononuclear cells

RAGE receptor for AGE

ROS reactive oxygen species

S-casein sorbitol casein

SD standard deviation

TBE tris-borate-EDTA

TBS tris-buffered saline

References

  • 1 Ahmed N, Mirshekar-Syahkal B, Kennish L, Karachalias N, Babaei-Jadidi R, Thornalley P J. Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection.  Mol Nutr Food Res. 2005;  49 691-699
  • 2 Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P. Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.  Am J Clin Nutr. 2004;  79 682-690
  • 3 Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert P M, Chen J, Hong M, Luther T, Henle T, Kloting I. et al . Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.  Diabetes. 2001;  50 2792-2808
  • 4 Cai W, Gao Q D, Zhu L, Peppa M, He C, Vlassara H. Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction.  Mol Med. 2002;  8 337-346
  • 5 Careche M, Lobato M F, Ros M, Moreno F J, Garcia-Ruiz J P. Influence of starvation/refeeding transition on lipogenesis and NADPH producing systems in adipose tissue, mammary gland and liver at mid-lactation.  Horm Metab Res. 1985;  17 226-229
  • 6 Ceriello A, Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Esposito K, Giugliano D. Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment.  Diabetes. 2004;  53 701-710
  • 7 Chung H Y, Kim H J, Kim J W, Yu B P. The inflammation hypothesis of aging: molecular modulation by calorie restriction.  Ann NY Acad Sci. 2001;  928 327-335
  • 8 Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V. Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.  J Clin Endocrinol Metab. 2001;  86 2899-2902
  • 9 Devasagayam T P, Tilak J C, Boloor K K, Sane K S, Ghaskadbi S S, Lele R D. Free radicals and antioxidants in human health: current status and future prospects.  J Assoc Physicians India. 2004;  52 794-804
  • 10 Exton M S, von Horsten S, Strubel T, Donath S, Schedlowski M, Westermann J. Conditioned alterations of specific blood leukocyte subsets are reconditionable.  Neuroimmunomodulation. 2000;  7 106-114
  • 11 Faist V, Muller C, Drusch S, Erbersdobler H F. Selective fortification of lysinoalanine, fructoselysine and N epsilon-carboxymethyllysine in casein model systems.  Nahrung. 2001;  45 218-221
  • 12 Friedman M, Grosjean O K, Zahnley J C. Inactivation of metalloenzymes by food constituents.  Food Chem Toxicol. 1986;  24 897-902
  • 13 Goldberg T, Cai W, Peppa M, Dardaine V, Baliga B S, Uribarri J, Vlassara H. Advanced glycoxidation end products in commonly consumed foods.  J Am Diet Assoc. 2004;  104 1287-1291
  • 14 He C, Sabol J, Mitsuhashi T, Vlassara H. Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration.  Diabetes. 1999;  48 1308-1315
  • 15 Henle T, Miyata T. Advanced glycation end products in uremia.  Adv Ren Replace Ther. 2003;  10 321-331
  • 16 Henle T. AGEs in foods: do they play a role in uremia?.  Kidney Int Suppl . 2003;  S145-147
  • 17 Hofmann M A, Schiekofer S, Isermann B, Kanitz M, Henkels M, Joswig M, Treusch A, Morcos M, Weiss T, Borcea V. et al . Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.  Diabetologia. 1999;  42 222-232
  • 18 Hofmann M A, Schiekofer S, Kanitz M, Klevesath M S, Joswig M, Lee V, Morcos M, Tritschler H, Ziegler R, Wahl P. et al . Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes.  Diabetes Care. 1998;  21 1310-1316
  • 19 Hofmann S M, Dong H J, Li Z, Cai W, Altomonte J, Thung S N, Zeng F, Fisher E A, Vlassara H. Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.  Diabetes. 2002;  51 2082-2089
  • 20 Hofmann T, Bors W, Stettmaier K. Radical-assisted melanoidin formation during thermal processing of foods as well as under physiological conditions.  J Agric Food Chem. 1999;  47 391-396
  • 21 Koschinsky T, He C J, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H. Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy.  Proc Natl Acad Sci USA. 1997;  94 6474-6479
  • 22 Kumar A, Takada Y, Boriek A M, Aggarwal B B. Nuclear factor-kappaB: its role in health and disease.  J Mol Med. 2004;  82 434-448
  • 23 McCarty M F. The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production.  Med Hypotheses. 2005;  64 394-398
  • 24 Miyata T, Ueda Y, Shinzato T, Lida Y, Tanaka S, Kurokawa K, van Ypersele de Strihou C, Maeda K. Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.  J Am Soc Nephrol. 1996;  7 1198-1206
  • 25 Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P. Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells.  Am J Clin Nutr. 2002;  75 767-772
  • 26 Mohanty P, Hamouda W, Garg R, Aljada A, Ghanim H, Dandona P. Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes.  J Clin Endocrinol Metab. 2000;  85 2970-2973
  • 27 Nappo F, Esposito K, Cioffi M, Giugliano G, Molinari A M, Paolisso G, Marfella R, Giugliano D. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals.  J Am Coll Cardiol. 2002;  39 1145-1150
  • 28 Nestares T, Lopez-Jurado M, Urbano G, Seiquer I, Ramirez-Tortosa M C, Ros E, Mataix J, Gil A. Effects of lifestyle modification and lipid intake variations on patients with peripheral vascular disease.  Int J Vitam Nutr Res. 2003;  73 389-398
  • 29 Pahl H L, Baeuerle P A. The ER-overload response: activation of NF-kappa B.  Trends Biochem Sci. 1997;  22 63-67
  • 30 Peppa M, Brem H, Ehrlich P, Zhang J G, Cai W, Li Z, Croitoru A, Thung S, Vlassara H. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice.  Diabetes. 2003;  52 2805-2813
  • 31 Peppa M, Goldberg T, Cai W, Rayfield E, Vlassara H. Glycotoxins: a missing link in the “relationship of dietary fat and meat intake in relation to risk of type 2 diabetes in men”.  Diabetes Care. 2002;  25 1898-1899
  • 32 Rudofsky Jr G, Reismann P, Schiekofer S, Petrov D, Eynatten M, Humpert P M, Isermann B, Muller-Hoff C, Thai T P, Lichtenstein S. et al . Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces NF-kappaB activation in PBMCs.  Horm Metab Res. 2004;  36 630-638
  • 33 Schiekofer S, Andrassy M, Chen J, Rudofsky G, Schneider J, Wendt T, Stefan N, Humpert P, Fritsche A, Stumvoll M. et al . Acute hyperglycemia causes intracellular formation of CML and activation of ras, p 42/44 MAPK, and nuclear factor kappaB in PBMCs.  Diabetes. 2003;  52 621-633
  • 34 Schleicher E D, Wagner E, Nerlich A G. Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.  J Clin Invest. 1997;  99 457-468
  • 35 Schmidt A M, Yan S D, Yan S F, Stern D M. The biology of the receptor for advanced glycation end products and its ligands.  Biochim Biophys Acta. 2000;  1498 99-111
  • 36 Sebekova K, Krajcoviova-Kudlackova M, Schinzel R, Faist V, Klvanova J, Heidland A. Plasma levels of advanced glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet.  Eur J Nutr. 2001;  40 275-281
  • 37 Stern D, Yan S D, Yan S F, Schmidt A M. Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings.  Adv Drug Deliv Rev. 2002;  54 1615-1625
  • 38 Talior I, Yarkoni M, Bashan N, Eldar-Finkelman H. Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice.  Am J Physiol Endocrinol Metab. 2003;  285 E295-302
  • 39 Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, Baliga S, Vassalotti J A, Vlassara H. Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.  Am J Kidney Dis. 2003;  42 532-538
  • 40 Vidal-Puig A J, Grujic D, Zhang C Y, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R. et al . Energy metabolism in uncoupling protein 3 gene knockout mice.  J Biol Chem. 2000;  275 16258-16266
  • 41 Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield E J. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.  Proc Natl Acad Sci USA. 2002;  99 15596-15601
  • 42 Zhang X, Frischmann M, Kientsch-Engel R, Steinmann K, Stopper H, Niwa T, Pischetsrieder M. Two immunochemical assays to measure advanced glycation end-products in serum from dialysis patients.  Clin Chem Lab Med. 2005;  43 503-511
  • 43 Zheng F, He C, Cai W, Hattori M, Steffes M, Vlassara H. Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products.  Diabetes Metab Res Rev. 2002;  18 224-237
  • 44 Zill H, Bek S, Hofmann T, Huber J, Frank O, Lindenmeier M, Weigle B, Erbersdobler H F, Scheidler S, Busch A E. et al . RAGE-mediated MAPK activation by food-derived AGE and non-AGE products.  Biochem Biophys Res Commun. 2003;  300 311-315

PhD Angelika Bierhaus

Department of Medicine I
University of Heidelberg

Im Neuenheimer Feld 410

69120 Heidelberg

Germany

Telefon: 0049(0)6221-56-4752

Fax: 00 49 (0) 62 21-56-47 54

eMail: angelika_bierhaus@med.uni-heidelberg.de

    >