Geburtshilfe Frauenheilkd 2006; 66(4): R61-R88
DOI: 10.1055/s-2006-924113
GebFra-Refresher

Georg Thieme Verlag KG Stuttgart · New York

Endometriose

S. P. Renner1 , P. Oppelt1 , H. Binder1 , M. W. Beckmann1
  • 1Frauenklinik Universität Erlangen, Erlangen
Further Information

Publication History

Publication Date:
11 May 2006 (online)

Obwohl die Endometriose erstmals bereits im späten 17. Jahrhundert beschrieben wurde, wird diese Erkrankung bis heute aufgrund des leider weitgehend fehlenden wissenschaftlichen und klinischen Interesses häufig als „forgotten disease“ bezeichnet [[1]]. Selbst in aktuellen Abhandlungen über Erkrankungen des Menschen (Encyclopedia of Medical History, 1985 und The Cambridge World History of Human Disease, 1993) sucht man vergebens nach einem Hinweis auf Endometriose [[2], [3]]. Angesichts der hohen Prävalenz der Erkrankung erscheint dies verwunderlich. Ein Grund liegt sicherlich in der weitgehend unverstandenen Ätiologie sowie der schwierigen Diagnostik und Therapie dieser rätselhaften Erkrankung. Dieser Refresher soll eine kurze, sicherlich nicht allumfassende Darstellung der Erkrankung geben, um sie weiter in den Mittelpunkt des klinischen und basiswissenschaftlichen Interesses zu rücken. Dies scheint aufgrund des hohen Leidensdruckes der Patientinnen sowie nicht zuletzt auch der hohen volkswirtschaftlichen Bedeutung der Endometriose durch Arbeitsausfall und medizinischen Aufwand mehr als überfällig zu sein.

Literatur

  • 1 Knapp V J. How old is endometriosis? Late 17th- and 18th-century European descriptions of the disease.  Fertil Steril. 1999;  72 10-14
  • 2 Kiple K. The Cambridge World History of Human Disease. Cambridge; Cambridge University Press 1993
  • 3 McGrew R. Encyclopedia of medical history. New York; McGraw-Hill 1985
  • 4 Mahmood T A, Templeton A. Prevalence and genesis of endometriosis.  Hum Reprod. 1991;  6 544-549
  • 5 Moen M H, Schei B. Epidemiology of endometriosis in a Norwegian county.  Acta Obstet Gynecol Scand. 1997;  76 559-562
  • 6 Vigano P, Parazzini F, Somigliana E, Vercellini P. Endometriosis: epidemiology and aetiological factors.  Best Pract Res Clin Obstet Gynaecol. 2004;  18 177-200
  • 7 Witz C A, Burns W N. Endometriosis and infertility: is there a cause and effect relationship?.  Gynecol Obstet Invest. 2002;  53 (Suppl 1) 2-11
  • 8 Simpson J L, Elias S, Malinak L R, Buttram Jr V C. Heritable aspects of endometriosis. I. Genetic studies.  Am J Obstet Gynecol. 1980;  137 327-331
  • 9 Meyer R. Über den Stand der Frage der Adenomyositis, Adenomyome im Allgemeinen und insbesondere über Adenomyositis seroepithelialis und Adenomyometritis sarcomatosa.  Zentralbl Gynakol. 1919;  36 745-750
  • 10 Sampson J. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity.  Am J Obst Gynecol. 1927;  14 442-469
  • 11 D'Hooghe T M, Bambra C S, Raeymaekers B M, De Jonge I, Lauweryns J M, Koninckx P R. Intrapelvic injection of menstrual endometrium causes endometriosis in baboons (Papio cynocephalus and Papio anubis).  Am J Obstet Gynecol. 1995;  173 125-134
  • 12 Sharpe-Timms K L. Using rats as a research model for the study of endometriosis.  Ann N Y Acad Sci. 2002;  955 318-327 340-312 396-406
  • 13 American_Society_for_Reproductive_Medicine . Revised American Society for Reproductive Medicine classification of endometriosis: 1996.  Fertil Steril. 1997;  67 817-821
  • 14 Tuttlies F, Keckstein J, Ulrich U. et al . [ENZIAN‐score, a classification of deep infiltrating endometriosis].  Zentralbl Gynakol. 2005;  127 275-281
  • 15 Schweppe K W. [Endometriosis - a disease that has no lobby].  Zentralbl Gynakol. 2003;  125 233
  • 16 Renner S P, Strick R, Oppelt P. et al . Evaluation of clinical parameters and estrogen receptor alpha gene polymorphisms for patients with endometriosis.  Reproduction. 2006;  131 153-161
  • 17 Sallam H, Garcia-Velasco J, Dias S, Arici A. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis.  Cochrane Database Syst Rev. 2006;  CD004635
  • 18 Alborzi S, Momtahan M, Parsanezhad M E, Dehbashi S, Zolghadri J, Alborzi S. A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas.  Fertil Steril. 2004;  82 1633-1637
  • 19 Saleh A, Tulandi T. Reoperation after laparoscopic treatment of ovarian endometriomas by excision and by fenestration.  Fertil Steril. 1999;  72 322-324
  • 20 Hart R, Hickey M, Maouris P, Buckett W, Garry R. Excisional surgery versus ablative surgery for ovarian endometriomata.  The Cochrane Database of Systematic Reviews. 2005;  3 CD004992 DOI: 10.1002/14651858.CD004992.pub2
  • 21 Mueller A, Thiel F, Binder H. et al . GebFra-Refresher Myome - Teil 1.  Geburtsh Frauenheilk. 2004;  64 R229-R244
  • 22 Mueller A, Oppelt P, Ackermann S, Binder H, Beckmann M W. The Hohl instrument for optimizing total laparoscopic hysterectomy procedures.  J Minim Invasive Gynecol. 2005;  12 432-435
  • 23 Mueller A, Thiel F, Binder H. et al . GebFra-Refresher Myome - Teil 2.  Geburtsh Frauenheilk. 2004;  64 R245-R260
  • 24 Schweppe K W. [Guidelines for the use of GnRH‐analogues in the treatment of endometriosis].  Zentralbl Gynakol. 2005;  127 308-313
  • 25 Zupi E, Marconi D, Sbracia M. et al . Add-back therapy in the treatment of endometriosis-associated pain.  Fertil Steril. 2004;  82 1303-1308
  • 26 Busacca M, Somigliana E, Bianchi S. et al . Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III - IV: a randomized controlled trial.  Hum Reprod. 2001;  16 2399-2402
  • 27 Hornstein M D, Yuzpe A A, Burry K A, Heinrichs L R, Buttram Jr V L, Orwoll E S. Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain.  Fertil Steril. 1995;  63 955-962
  • 28 Vercellini P, Crosignani P G, Fadini R, Radici E, Belloni C, Sismondi P. A gonadotrophin-releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis.  Br J Obstet Gynaecol. 1999;  106 672-677
  • 29 Hornstein M D, Hemmings R, Yuzpe A A, Heinrichs W L. Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis.  Fertil Steril. 1997;  68 860-864
  • 30 Hornstein M D, Surrey E S, Weisberg G W, Casino L A. Leuprolide acetate depot and hormonal add-back in endometriosis: a 12-month study. Lupron Add-Back Study Group.  Obstet Gynecol. 1998;  91 16-24
  • 31 Moore J, Kennedy S, Prentice A. Modern combined oral contraceptives for pain associated with endometriosis.  Cochrane Database Syst Rev. 2000;  2 CD001019
  • 32 Fedele L, Berlanda N. Emerging drugs for endometriosis.  Expert Opin Emerg Drugs. 2004;  9 167-177
  • 33 Goretzlehner G. [Menstrual bleeding - must that be? Extended use of oral hormonal contraceptives].  Zentralbl Gynakol. 2005;  127 302-307
  • 34 Anderson F D, Hait H. A multicenter, randomized study of an extended cycle oral contraceptive.  Contraception. 2003;  68 89-96
  • 35 Mahutte N G, Arici A. Medical management of endometriosis-associated pain.  Obstet Gynecol Clin North Am. 2003;  30 133-150
  • 36 Prentice A, Deary A J, Bland E. Progestagens and anti-progestagens for pain associated with endometriosis.  Cochrane Database Syst Rev. 2000;  2 CD002122
  • 37 Regidor P A, Regidor M, Schmidt M. et al . Prospective randomized study comparing the GnRH‐agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis.  Gynecol Endocrinol. 2001;  15 202-209
  • 38 Vercellini P, Fedele L, Pietropaolo G, Frontino G, Somigliana E, Crosignani P G. Progestogens for endometriosis: forward to the past.  Hum Reprod Update. 2003;  9 387-396
  • 39 Vercellini P, Vigano P, Somigliana E. The role of the levonorgestrel-releasing intrauterine device in the management of symptomatic endometriosis.  Curr Opin Obstet Gynecol. 2005;  17 359-365
  • 40 Petta C A, Ferriani R A, Abrao M S. et al . Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis.  Hum Reprod. 2005;  20 1993-1998
  • 41 Allen C, Hopewell S, Prentice A, Allen C. Non-steroidal anti-inflammatory drugs for pain in women with endometriosis.  Cochrane Database Syst Rev. 2005;  4 CD004753
  • 42 Sagsveen M, Farmer J E, Prentice A, Breeze A. Gonadotrophin-releasing hormone analogues for endometriosis: bone mineral density.  Cochrane Database Syst Rev. 2003;  CD001297
  • 43 Attar E, Bulun S E. Aromatase and other steroidogenic genes in endometriosis: translational aspects.  Hum Reprod Update. 2005;  12 49-56
  • 44 Ebert A D, Bartley J, David M. Aromatase inhibitors and cyclooxygenase-2 (COX‐2) inhibitors in endometriosis: new questions - old answers?.  Eur J Obstet Gynecol Reprod Biol. 2005;  122 144-150
  • 45 Pritts E A, Taylor R N. An evidence-based evaluation of endometriosis-associated infertility.  Endocrinol Metab Clin North Am. 2003;  32 653-667
  • 46 Omland A K, Tanbo T, Dale P O, Abyholm T. Artificial insemination by husband in unexplained infertility compared with infertility associated with peritoneal endometriosis.  Hum Reprod. 1998;  13 2602-2605
  • 47 Wu M Y, Ho H N. The role of cytokines in endometriosis.  Am J Reprod Immunol. 2003;  49 285-296
  • 48 Kissler S, Hamscho N, Zangos S. et al . Diminished pregnancy rates in endometriosis due to impaired uterotubal transport assessed by hysterosalpingoscintigraphy.  Bjog. 2005;  112 1391-1396
  • 49 Garrido N, Navarro J, Garcia-Velasco J, Remoh J, Pellice A, Simon C. The endometrium versus embryonic quality in endometriosis-related infertility.  Hum Reprod Update. 2002;  8 95-103
  • 50 Garcia-Velasco J A, Mahutte N G, Corona J. et al . Removal of endometriomas before in vitro fertilization does not improve fertility outcomes: a matched, case-control study.  Fertil Steril. 2004;  81 1194-1197
  • 51 Simon C, Gutierrez A, Vidal A. et al . Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation.  Hum Reprod. 1994;  9 725-729
  • 52 Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization.  Fertil Steril. 2002;  77 1148-1155
  • 53 Yap C, Furness S, Farquhar C. Pre and post operative medical therapy for endometriosis surgery.  The Cochrane Database of Systematic Reviews. 2000;  2 CD003678 DOI: 10.1002/14651858.CD003678
  • 54 Hughes E, Fedorkow D, Collins J, Vandekerckhove P. Ovulation suppression for endometriosis.  The Cochrane Database of Systematic Reviews. 2003;  3 CD000155 DOI: 10.1002/14651858.CD000155
  • 55 Rickes D, Nickel I, Kropf S, Kleinstein J. Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis.  Fertil Steril. 2002;  78 757-762
  • 56 Hughes E G, Fedorkow D M, Collins J A. A quantitative overview of controlled trials in endometriosis-associated infertility.  Fertil Steril. 1993;  59 963-970
  • 57 Jacobson T, Barlow D, Koninckx P, Olive D, Farquhar C. Laparoscopic surgery for subfertility associated with endometriosis.  The Cochrane Database of Systematic Reviews. 2002;  4 CD001398 DOI: 10.1002/14651858.CD001398
  • 58 Strowitzki T. [Infertility treatment and endometriosis - risk and benefit of assisted reproductive techniques].  Zentralbl Gynakol. 2005;  127 314-319
  • 59 Deaton J L, Gibson M, Blackmer K M, Nakajima S T, Badger G J, Brumsted J R. A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis.  Fertil Steril. 1990;  54 1083-1088
  • 60 Tummon I S, Asher L J, Martin J S, Tulandi T. Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis.  Fertil Steril. 1997;  68 8-12
  • 61 Jansen R P. Relative infertility: modeling clinical paradoxes.  Fertil Steril. 1993;  59 1041-1045
  • 62 Somigliana E, Vercellini P, Vigano P, Ragni G, Giorgio Crosignani P. Should endometriomas be treated before IVF-ICSI cycles?.  Hum Reprod Update 2005;. 2006;  12 57-64

Dr. Stefan P. Renner

Frauenklinik Universität Erlangen

Universitätsstraße 21 - 23

91054 Erlangen

Email: Stefan.Renner@gyn.imed.uni-erlangen.de

    >