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DOI: 10.1055/s-2006-924957
© Georg Thieme Verlag Stuttgart · New York
Peri-interventionelles Risiko von Herzkatheteruntersuchungen bei ≥ 80-jährigen Patienten
Peri-interventional risk in 1 384 cardiac catheterizations in patients aged 80 years or olderPublication History
eingereicht: 29.11.2004
akzeptiert: 16.12.2005
Publication Date:
06 February 2006 (online)

Zusammenfassung
Hintergrund: Aufgrund der gestiegenen Lebenserwartung in den industrialisierten Ländern werden immer mehr Herzkatheteruntersuchungen bei Patienten ≥ 80 Jahren durchgeführt. Über die Häufigkeit von peri-interventionellen Ereignissen ist nur wenig bekannt.
Patienten und Methodik: In unserer Klinik wurden zwischen Januar 1996 und September 2000 bei 1085 Patienten im Alter von ≥80 Jahren (82,6 ± 2,6 Jahre) 1384 Herzkatheteruntersuchungen und Interventionen (3 % der insgesamt 43 517 Herzkatheteruntersuchungen) durchgeführt.
Ergebnisse: 827 Patienten (77 %) hatten signifikante Koronarstenosen. 373 (45 %) dieser Patienten wurden mit Ballonangioplastie/Stentimplantation behandelt, 331 (40 %) erhielten eine aortokoronare Bypassoperation. Während des Krankenhausaufenthaltes starben 31 Patienten, von denen bereits zum Aufnahmezeitpunkt 17 Patienten im kardiogenen Schock waren. Peri-interventionelle Ereignisse einschließlich Gefäßverletzungen an den Punktionsstellen gab es bei 2,1 % der Patienten bei einer diagnostischen Herzkatheteruntersuchung und bei 11,6 % nach perkutaner Intervention.
Folgerung: Die Ergebnisse zeigen, dass auch bei Patienten im Alter von ≥ 80 Jahren sowohl Herzkatheteruntersuchungen als auch Interventionen mit einem vertretbaren Risiko durchgeführt werden können. Diese Untersuchungen sollten dieser Altersgruppe nicht vorenthalten werden.
Summary
Background and objective: Because of the rising life expectancy in the industrialized countries, ever more cardiac catheterizations are performed in patients aged 80 years or older. Little is known about the incidence of peri-interventional events in this age group.
Patients and methods: Between January 1996 and September 2000, a total of 1 085 patients of that age (mean 82.6 2.6 years) underwent cardiac catheterization and intervention (3% of a total of 43517 cardiac catheterizations).
Results: 827 patients (77%) had significant coronary artery stenoses. 373 of them (45%) were treated with balloon angioplasty, with or without stenting, and 331 (40%) underwent aortocoronary bypass procedures. 31 patients died while in hospital, 17 of them having been in cardiogenic shock on admission. Peri-interventional events, including damage to artery at the site of catheter entry occurred in 2.1% of patients undergoing diagnostic cardiac catheterization and in 11.6% in connection with a percutaneous interventional procedure.
Conclusion: Both cardiac catheterization and interventional procedures can be done with a justifiable risk in patients aged 80 years or older. These cardiac investigations/interventions should not be withheld in this group of patients for reasons of age.
Literatur
- 1
Batchelor W B, Anstrom K J, Muhlbaier L H. et al .
Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions:
results in 7,472 octogenarians. National Cardiovascular Network Collaboration.
J Am Coll Cardiol.
2000;
36
723-730
MissingFormLabel
- 2
Bedotto J B, Rutherford B D, McConahay D R. et al .
Results of multivessel percutaneous transluminal coronary angioplasty in persons aged
65 years and older.
Am J Cardiol.
1991;
67
1051-1055
MissingFormLabel
- 3
Boersma E, Pieper K S, Steyerberg E W. et al .
Predictors of outcome in patients with acute coronary syndromes without persistent
ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT
Investigators.
Circulation.
2000;
101
2557-2567
MissingFormLabel
- 4
Ellis S G, Elliott J, Horrigan M, Raymond R E, Howell G.
Low-normal or excessive body mass index: newly identified and powerful risk factors
for death and other complications with percutaneous coronary intervention.
Am J Cardiol.
1996;
78
642-646
MissingFormLabel
- 5
Graham M M, Ghali W A, Faris P D, Galbraith P D, Norris C M, Knudtson M L.
Survival after coronary revascularization in the elderly.
Circulation.
2002;
105
2378-2384
MissingFormLabel
- 6
Haffner S M, Lehto S, Ronnemaa T, Pyorala K, Laakso M.
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic
subjects with and without prior myocardial infarction.
N Engl J Med.
1998;
339
229-234
MissingFormLabel
- 7
Kelsey S F, Miller D P, Holubkov R, Lu A S, Cowley M J, Faxon D P, Detre K M.
Results of percutaneous transluminal coronary angioplasty in patients greater than
or equal to 65 years of age (from the 1985 to 1986 National Heart, Lung, and Blood
Institute’s Coronary Angioplasty Registry).
Am J Cardiol.
1990;
66
1033-1038
MissingFormLabel
- 8
Kimmel S E, Berlin J A, Laskey W K.
The relationship between coronary angioplasty procedure volume and major complications.
Jama.
1995;
274
1137-1142
MissingFormLabel
- 9
Kip K E, Faxon D P, Detre K M, Yeh W, Kelsey S F, Currier J W.
Coronary angioplasty in diabetic patients. The National Heart, Lung, and Blood Institute
Percutaneous Transluminal Coronary Angioplasty Registry.
Circulation.
1996;
94
1818-1825
MissingFormLabel
- 10
Lee P Y, Alexander K P, Hammill B G, Pasquali S K, Peterson E D.
Representation of elderly persons and women in published randomized trials of acute
coronary syndromes.
Jama.
2001;
286
708-713
MissingFormLabel
- 11
Lefevre T, Morice M C, Eltchaninoff H. et al .
One-month results of coronary stenting in patients > or = 75 years of age.
Am J Cardiol.
1998;
82
17-21
MissingFormLabel
- 12
Lincoff A M, Califf R M, Anderson K M. et al .
Evidence for prevention of death and myocardial infarction with platelet membrane
glycoprotein IIb/IIIa receptor blockade by abciximab (c7E3 Fab) among patients with
unstable angina undergoing percutaneous coronary revascularization: EPIC Investigators.
Evaluation of 7E3 in Preventing Ischemic Complications.
J Am Coll Cardiol.
1997;
30
149-156
MissingFormLabel
- 13
Mak K H, Moliterno D J, Granger C B. et al .
Influence of diabetes mellitus on clinical outcome in the thrombolytic era of acute
myocardial infarction. GUSTO-I Investigators. Global Utilization of Streptokinase
and Tissue Plasminogen Activator for Occluded Coronary Arteries.
J Am Coll Cardiol.
1997;
30
171-179
MissingFormLabel
- 14
McGuire D K, Emanuelsson H, Granger C B. et al .
Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary
syndromes. Findings from the GUSTO-IIb study. GUSTO IIb Investigators.
Eur Heart J.
2000;
21
1750-1758
MissingFormLabel
- 15
Mills T J, Smith H C, Vlietstra R E.
PTCA in the elderly: results and expectations.
Geriatrics.
1989;
44
71-72, 77 - 79
MissingFormLabel
- 16
Morrison D A, Bies R D, Sacks J.
Coronary angioplasty for elderly patients with „high risk” unstable angina: short-term
outcomes and long-term survival.
J Am Coll Cardiol.
1997;
29
339-344
MissingFormLabel
- 17
Peterson E D, Jollis J G, Bebchuk J D. et al .
Changes in mortality after myocardial revascularization in the elderly. The national
Medicare experience.
Ann Intern Med.
1994;
121
919-927
MissingFormLabel
- 18
ten Berg J M, Voors A A, Suttorp M J. et al .
Long-term results after successful percutaneous transluminal coronary angioplasty
in patients over 75 years of age.
Am J Cardiol.
1996;
77
690-695
MissingFormLabel
- 19
Thompson R C, Holmes D R, Gersh B J, Bailey K R.
Predicting early and intermediate-term outcome of coronary angioplasty in the elderly.
Circulation.
1993;
88
1579-1587
MissingFormLabel
- 20
Thompson R C, Holmes D R, Gersh B J, Mock M B, Bailey K R.
Percutaneous transluminal coronary angioplasty in the elderly: early and long-term
results.
J Am Coll Cardiol.
1991;
17
1245-1250
MissingFormLabel
- 21
Weaver W D, Litwin P E, Martin J S. et al .
Effect of age on use of thrombolytic therapy and mortality in acute myocardial infarction.
The MITI Project Group.
J Am Coll Cardiol.
1991;
18
657-662
MissingFormLabel
- 22
Weintraub W S, Stein B, Kosinski A. et al .
Outcome of coronary bypass surgery versus coronary angioplasty in diabetic patients
with multivessel coronary artery disease.
J Am Coll Cardiol.
1998;
31
10-19
MissingFormLabel
Prof. Dr. Dr. Josef Niebauer
Universitätsinstitut für präventive und rehabilitative Sportmedizin, Paracelsus Medizinische
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