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Horm Metab Res 2006; 38(4): 279-290
DOI: 10.1055/s-2006-925348
DOI: 10.1055/s-2006-925348
Review
© Georg Thieme Verlag KG Stuttgart · New YorkThe Role of Plasma-binding Proteins in the Cellular Uptake of Lipophilic Vitamins and Steroids
Further Information
Publication History
Received 19 October 2005
Accepted after revision 20 February 2006
Publication Date:
15 May 2006 (online)
Abstract
Steroid hormones and many other lipophilic compounds are believed to enter cells solely by free diffusion through the plasma membrane. However, recent work using a megalin-deficient mouse model has identified a new endocytic pathway responsible for the delivery of steroids to renal and gonadal tissues. This review describes these new pathways for uptake of 25-hydroxy-vitamin-D3 and the gonadal sex-steroids (17β-estradiol and testosterone) bound to vitamin D-binding protein and sex hormone-binding globulin respectively. Furthermore examples of other lipophilic molecules that enter cells by receptor-mediated pathways will be presented and the receptors responsible for their uptake described.
Key words
SHBG · DBP · steroids · lipophilic molecules · binding proteins · receptor-mediated endocytosis · uptake · transport
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Thomas K. Andreassen
Department of Medical Biochemistry · University of Aarhus
Ole Worms Alle · Bldg 1170 · 8000 Aarhus C · Denmark
Phone: +45(89)422873
Fax: +45(86)131160
Email: tka@biokemi.au.dk