Semin Neurol 2006; 26(3): 341-350
DOI: 10.1055/s-2006-945520
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Psychogenic (Nonepileptic) Seizures

Allan Krumholz1 , Jennifer Hopp1
  • 1Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland
Further Information

Publication History

Publication Date:
22 June 2006 (online)

ABSTRACT

Psychogenic (nonepileptic) seizures are among the most common and serious of all psychogenic neurological disorders. They account for ~20% of all intractable seizure disorders referred to comprehensive epilepsy centers and present with a reported annual incidence of ~4% that of true epilepsy. These events are serious and disabling. Indeed, compared with patients with true epilepsy, patients with psychogenic seizures exhibit more frequent, severe, and disabling seizures as well as a poorer quality of life. The diagnosis and management of psychogenic seizures remain challenging, although advances in video electroencephalographic (EEG) monitoring have improved the ability of physicians to identify these disorders accurately. The prognosis of these patients is still relatively poor, and a good outcome seems dependent on a young age at diagnosis, early diagnosis, less severe psychological comorbidities, and continued follow-up and management by the diagnosing neurologist or clinician. Additional psychological or psychiatric assessment may be beneficial, particularly in elucidating the etiology of the disorder as well as identifying comorbid disorders, and may help in the long-term management of these patients. This review presents the history, epidemiology, differential diagnosis, and management of psychogenic seizures, with particular attention to the use of diagnostic testing, including video EEG monitoring.

REFERENCES

  • 1 Krumholz A. Nonepileptic seizures: diagnosis and management.  Neurology. 1999;  53(suppl 2) S76-S83
  • 2 Meierkord H, Will B, Fish D, Shorvon S. The clinical features and prognosis of pseudoseizures diagnosed using video-EEG telemetry.  Neurology. 1991;  41 1643-1646
  • 3 Lesser R P. Psychogenic seizures.  Neurology. 1996;  46 1499-1507
  • 4 Sigurdardottir K R, Olafsson E. Incidence of psychogenic seizures in adults: a population-based study in Iceland.  Epilepsia. 1998;  39 749-752
  • 5 Szaflarski J P, Szaflarski M, Hughes C, Ficker D M, Cahill W T, Privitera M D. Psychopathology and quality of life: psychogenic non-epileptic seizures versus epilepsy.  Med Sci Monit. 2003;  9 CR113-CR118
  • 6 Barry E, Krumholz A, Bergey C, Alemayehu S, Grattan L. Nonepileptic posttraumatic seizures.  Epilepsia. 1998;  39 427-431
  • 7 Pakalnis A, Drake M E, Phillips B. Neuropsychiatric aspects of psychogenic status epilepticus.  Neurology. 1991;  41 1104-1106
  • 8 Walczak T S, Papacostas S, Williams D T et al.. Outcome after the diagnosis of psychogenic nonepileptic seizures.  Epilepsia. 1995;  36 1131-1137
  • 9 Metrick M E, Ritter F J, Gates J R et al.. Nonepileptic events in childhood.  Epilepsia. 1991;  32 322-328
  • 10 Wyllie E, Friedman D, Luders H et al.. Outcome of psychogenic seizures in children and adolescents compared to adults.  Neurology. 1991;  41 742-744
  • 11 Slavney P R. Perspectives on Hysteria. Baltimore; The Johns Hopkins University Press 1990
  • 12 Veith I. Hysteria: The History of a Disease. Chicago; University of Chicago Press 1965
  • 13 Alper K, Devinsky O, Perrine K, Vazquez B, Luciano D. Nonepileptic seizures and childhood sexual and physical abuse.  Neurology. 1993;  43 1950-1953
  • 14 Westbrook L E, Devinsky O, Geocadin R. Nonepileptic seizures after head injury.  Epilepsia. 1998;  39 978-982
  • 15 Goetz C G. Charcot the Clinician: The Tuesday Lessons. New York; Raven Press 1987
  • 16 Massey E W, McHenry L C. Hysteroepilepsy in the nineteenth century: Charcot and Gowers.  Neurology. 1986;  36 65-67
  • 17 Ziegler F J, Imboden J B, Meyer E. Contemporary conversion reactions: a clinical study.  Am J Psychiatry. 1960;  116 901-910
  • 18 Liske E, Forster F M. Pseudoseizures: a problem in the diagnosis and management of epileptic patients.  Neurology. 1964;  14 41-49
  • 19 Diagnostic and Statistical Manual of Mental Disorders .DSM-IV. 4th ed. Washington, DC; American Psychiatric Association 1995
  • 20 Krumholz A, Niedermeyer E. Psychogenic seizures: a clinical study with follow-up data.  Neurology. 1983;  33 498-502
  • 21 Krumholz A, Ting T. Co-existing epileptic and nonepileptic seizures. In: Kaplan PW, Fisher RS Imitators of Epilepsy. 2nd ed. New York; Demos Medical Publishing 2005: 261-276
  • 22 Gates J R, Ramani V, Whalen S, Loewenson R. Ictal characteristics of pseudoseizures.  Arch Neurol. 1985;  42 1183-1187
  • 23 Leis A A, Ross M A, Summers A K. Psychogenic seizures: ictal characteristics and diagnostic pitfalls.  Neurology. 1992;  42 95-99
  • 24 Walczak T S, Bogolioubov A. Weeping during psychogenic nonepileptic seizures.  Epilepsia. 1996;  37 208-210
  • 25 Bergen D, Ristanovic R. Weeping is a common element during psychogenic nonepileptic seizures.  Arch Neurol. 1993;  50 1059-1060
  • 26 Peguero E, Abou-Khalil B, Fakhoury T, Mathews G. Self-injury and incontinence in psychogenic seizures.  Epilepsia. 1995;  36 586-591
  • 27 Orbach D, Ritaccio A, Devinsky O. Psychogenic, nonepileptic seizures associated with video-EEG-verified sleep.  Epilepsia. 2003;  44 64-68
  • 28 Walczak T S, Williams D T, Berton W. Utility and reliability of placebo infusion in the evaluation of patients with seizures.  Neurology. 1994;  44 394-399
  • 29 Bazil C W, Kothari M, Luciano D et al.. Provocation of nonepileptic seizures by suggestion in a general seizure population.  Epilepsia. 1994;  35 768-770
  • 30 Devinsky O, Fisher R S. Ethical use of placebos and provocative testing in diagnosing nonepileptic seizures.  Neurology. 1996;  47 866-870
  • 31 Lesser R P, Lueders H, Dinner D S. Evidence for epilepsy is rare in patients with psychogenic seizures.  Neurology. 1983;  33 502-504
  • 32 Ramsay R E, Cohen A, Brown M C. Coexisting epilepsy and non-epileptic seizures. In: Rowan AJ, Gates JR Non-Epileptic Seizures. Boston; Butterworth-Heinemann 1993: 47-54
  • 33 Benbadis S R, Agrawal V, Tatum W O. How many patients with psychogenic nonepileptic seizures also have epilepsy?.  Neurology. 2001;  57 915-917
  • 34 Glosser G, Roberts D, Glosser D S. Nonepileptic seizures after resective epilepsy surgery.  Epilepsia. 1999;  40 1750-1754
  • 35 Reuber M, Kral T. New-onset psychogenic seizures after intracranial neurosurgery.  Acta Neurochir (Wien). 2002;  144 901-907
  • 36 Bare M A, Burnstine T H, Fisher R S, Lesser R P. Electroencephalographic changes during simple partial seizures.  Epilepsia. 1994;  35 715-720
  • 37 Krauss G L, Abdullah A, Lesser R, Thompson R E, Niedermeyer E. Clinical and EEG features of patients with EEG wicket rhythms misdiagnosed with epilepsy.  Neurology. 2005;  64 1879-1883
  • 38 Trimble M R. Serum prolactin in epilepsy and hysteria.  Br Med J. 1978;  2 1682
  • 39 Laxer K D, Mullooly J P, Howell B. Prolactin changes after seizures classified by EEG monitoring.  Neurology. 1985;  35 31-35
  • 40 Pritchard P B, Wannamaker B B, Sagel J, Nair R, DeVillier C. Endocrine function following complex partial seizures.  Ann Neurol. 1983;  14 27-32
  • 41 Malkowicz D E, Legido A, Jackel R A et al.. Prolactin secretion following repetitive seizures.  Neurology. 1995;  45 448-452
  • 42 Oribe E, Rohullah A, Nissenbaum E, Boal B. Serum prolactin concentrations are elevated after syncope.  Neurology. 1996;  47 60-62
  • 43 Henrichs T F, Tucker D M, Farha J, Novelly R A. MMPI indices in the identification of patients evidencing pseudoseizures.  Epilepsia. 1988;  29 184-188
  • 44 Wilkus R J, Dodrill C B. Factors affecting the outcome of MMPI and neuropsychological assessments of psychogenic and epileptic seizure patients.  Epilepsia. 1989;  30 339-347
  • 45 Aboukasm A, Mahr G, Gahry B R, Thomas A, Barkley G L. Retrospective analysis of the effects of psychotherapeutic interventions on outcomes of psychogenic nonepileptic seizures.  Epilepsia. 1998;  39 470-473
  • 46 Shen W, Bowman E S, Markand O N. Presenting the diagnosis of pseudoseizure.  Neurology. 1990;  40 756-759
  • 47 Bennet C, So N M, Smith W B, Thompson K. Structured treatment improves the outcome of nonepileptic events [abstract].  Epilepsia. 1997;  38(suppl 8) 214
  • 48 Reuber M, Pukrop T, Bauer J et al.. Outcome in psychogenic nonepileptic seizures: 1 to 10-year follow-up in 164 patients.  Ann Neurol. 2003;  53 305-311
  • 49 Bowman E S. Etiology and clinical course of pseudoseizures: relationship to trauma, depression, and dissociation.  Psychosomatics. 1993;  34 333-342
  • 50 Bowman E S, Markand O N. Psychodynamics and psychiatric diagnoses of pseudoseizure subjects.  Am J Psychiatry. 1996;  153 57-66
  • 51 Vanderzant C W, Giordani B, Berent S, Dreifuss F E, Sackellares J C. Personality of patients with pseudoseizures.  Neurology. 1986;  36 664-668
  • 52 Williamson P, Spencer D, Spencer S et al.. Complex partial seizures of frontal lobe origin.  Ann Neurol. 1985;  18 497-504
  • 53 Saygi S, Katz A, Marks D et al.. Frontal lobe partial seizures and psychogenic seizures: comparison of clinical and ictal characteristics.  Neurology. 1992;  42 1274-1277
  • 54 Waterman K, Purves S, Kosaka B et al.. An epileptic syndrome caused by mesial frontal lobe seizure foci.  Neurology. 1987;  37 577-582
  • 55 Sussman N, Jackel R, Kaplan L et al.. Bicycling movements as a manifestation of complex partial seizures of temporal lobe origin.  Epilepsia. 1989;  30 527-531

Allan KrumholzM.D. 

Department of Neurology, N4W46, University of Maryland Medical Center

22 South Greene Street, Baltimore, MD 21201

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