Intramolecular CH arylation of imidazole derivatives is carried out in the presence
of a palladium catalyst to form fused heteroaromatic compounds. The reaction of imidazole
with 2-iodobenzyl bromide with NaH gives the cyclization precursor in an excellent
yield. This then undergoes a palladium-catalyzed intramolecular CH arylation at 100
°C to form 5H-imidazo[5,1-a]isoindole in 78% yield.
intramolecular C-H arylation - palladium catalyst - imidazole derivatives - one-pot
reaction
