Dtsch Med Wochenschr 2006; 131(42): 2355-2358
DOI: 10.1055/s-2006-955016
Prinzip & Perspektive | Review article
Grundlagenforschung
© Georg Thieme Verlag KG Stuttgart · New York

CD8+ T-Zelldifferenzierung bei Virusinfektionen

CD8+ T cell differentiation in viral infectionsB. Bengsch1 , R. Thimme1
  • 1Abteilung Innere Medizin II, Universitätsklinik Freiburg
Further Information

Publication History

eingereicht: 10.4.2006

akzeptiert: 6.7.2006

Publication Date:
17 October 2006 (online)

Literatur

  • 1 Appay V, Dunbar P R, Callan M. et al . Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections.  Nat Med. 2002;  8 379-385
  • 2 Barber D L, Wherry E J, Masopust D. et al . Restoring function in exhausted CD8 T cells during chronic viral infection.  Nature. 2006;  439 682-687
  • 3 Boettler T, Panther E, Bengsch B. et al . Expression of IL-7 receptor a chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells in acute resolving hepatitis B virus infection.  J Virol. 2006;  80 3532-3540
  • 4 Gattinoni L, Klebanoff C A, Palmer D C. et al . Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells.  J Clin Invest. 2005;  115 1616-1626
  • 5 Kaech S M, Tan J T, Wherry E J, Konieczny B T, Surh C D, Ahmed R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.  Nat Immunol. 2003;  4 1191-1198
  • 6 Klenerman P, Hill A. T cells and viral persistence: lessons from diverse infections.  Nat Immunol. 2005;  6 873-879
  • 7 McMichael A J, Rowland-Jones S L. Cellular immune responses to HIV.  Nature. 2001;  410 980-987
  • 8 Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection.  Nat Rev Immunol. 2005;  5 215-229
  • 9 Schmitz J E, Kuroda M J, Santra S. et al . Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.  Science. 1999;  283 857-860
  • 10 Shoukry N H, Grakoui A, Houghton M. et al . Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection.  J Exp Med. 2003;  197 1645-1655
  • 11 Thimme R, Wieland S, Steiger C. et al . CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection.  J Virol. 2003;  77 68-76
  • 12 Thimme R, Appay V, Koschella M. et al . Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.  J Virol. 2005;  79 12112-12116
  • 13 Thimme R, Lohmann V, Weber F. A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus.  Antiviral Res. 2006;  69 129-141
  • 14 van Leeuwen E M, de Bree G J, Remmerswaal E B. et al . IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells.  Blood. 2005;  106 2091-2098

Prof. Dr. med. Robert Thimme

Universitätsklinikum Freiburg, Abteilung Innere Medizin II

Hugstetter Straße 55

79106 Freiburg

Phone: 0761/2703280

Fax: 0761/2703372

Email: thimme@med1.ukl.uni-freiburg.de

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