Dtsch Med Wochenschr 2006; 131(44): 2489-2492
DOI: 10.1055/s-2006-955038
Kommentar | Commentary
Intensivmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Organversagen Mikrozirkulation: Diagnostik und therapeutische Konsequenzen

Failure of microcirculation: Diagnosis and therapeutic consequencesJ. N. Hoffmann1 , J. M. Fertmann1 , K. Schick1 , M. Mauer1 , K. C. Wirsching1 , B. Vollmar2 , M. D. Menger3 , K. W. Jauch1
  • 11Chirurgische Klinik und Poliklinik, Klinikum der Universität München Großhadern
  • 32Institut für Experimentelle Chirurgie, Universität Rostock
  • 23Institut für Klinisch-Experimentelle Chirurgie, Universität des Saarlands
Weitere Informationen

Publikationsverlauf

eingereicht: 24.7.2006

akzeptiert: 20.10.2006

Publikationsdatum:
25. Oktober 2006 (online)

Literatur

  • 1 Angus D, Linde-Zwirble W T, Clermonte G, Carcillo J, Pinsky M R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.  Crit Care Med. 2001;  29 1303-1310
  • 2 Bernard G R, Vincent J L, Laterre P F. et al . Efficacy and safety of recombinant human activated protein C for severe sepsis.  N Engl J Med. 2001;  344 699-709
  • 3 Boerma E C, Mathura K R, van der Voort P. et al . Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients.  Crit. Care. 2005;  9 R601-R606
  • 4 de Backer D, Creteur J, Dubois M. et al . Microvascular alterations in patients with acute severe heart failure and cardiogenic shock.  Am Heart J. 2004;  147 91-99
  • 5 de Backer D, Creteur J, Preiser J C, Dubois M J, Vincent J L. Microvascular blood flow is altered in patients with sepsis.  Am J Respir Crit Care Med. 2002;  166 98-104
  • 6 de Backer D, Verdant C, Chierego M, Koch M, Gullo A, Vincent J L. Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis.  Crit Care Med. 2006;  34 1918-1924
  • 7 Dhainaut J -F, Yan S B, Margolt B D, Lorente J A, Russell J M. et al . Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulatory response in patients with severe sepsis.  Thromb Haemost. 2003;  90 642-650
  • 8 Granger D N, Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell interaction.  J Leukoc Biol. 1994;  55 662-675
  • 9 Groner W, Winkelman J W, Harris A G, Ince C, Bouma G J, Messmer K. et al . Orthogonal polarization spectral imaging.  Nature Med. 1999;  3 1209-1213
  • 10 Hoffmann J N. Therapeutische Optionen zur Verbesserung der Mikrozirkulation.  J Anästhesie Intensivbehandlung. 2004;  121-122
  • 11 Hoffmann J N, Vollmar B, Laschke M, Inthorn D, Fertmann J, Schildberg F W. et al . Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia.  Crit Care Med. 2004;  32 1011-1017
  • 12 Hoffmann J N, Vollmar B, Laschke M, Inthorn D, Kaneider N, Dunzendoerfer S. et al . Adverse effect of heparin on antithrombin action during endotoxemia: microhemodynamic and cellular mechanisms.  Thromb Haemost. 2002;  88 242-252
  • 13 Hoffmann J N, Wiedermann C J, Juers M. et al . Benefit/riskprofile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin.  Thromb Haemost. 2006;  95 850-856
  • 14 Iba T, Kidokoro A, Fukunaga M. Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model.  Crit Care Med. 2005;  33 368-372
  • 15 Ince C. The microcirculation is the motor of sepsis.  Critical Care. 2005;  9 S13-S19
  • 16 LeDoux D, Astiz M E, Carpati C M, Rackow E C. Effects of perfusion pressure on tissue perfusion in septic shock.  Crit Care Med. 2000;  28 2729-2733
  • 17 Rivers E, Nguyen B, Havstad S. et al . Early goal-directed therapy in the treatment of severe sepsis and septic shock.  N Engl J Med. 2001;  345 1368-1377
  • 18 Sakr Y, Dubois M, de Backer D. et al . Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock.  Crit Care Med. 2004;  32 1825-1831
  • 19 Vincent J L. Plugging the leaks? New insights into synthetic colloids.  Crit Care Med. 1991;  19 316-318
  • 20 White B, Schmidt M, Murphy C. et al . Activated protein C inhibits lipopolysaccharide induced nuclear translocation of nuclear factor kB (NF-kB) and tumor necrosis factor (TNF-alpha) production in the THP-1 monocytic cell line.  Br J Haematol. 2000;  110 130-134

Priv.-Doz. Dr. J. N. Hoffmann

Oberarzt, Chirurgische Klinik und Poliklinik - Großhadern, Universität München

Marchioninistraße 15

81377 München

Telefon: 089/70950

Fax: 089/70955706

eMail: Johannes.Hoffmann@med.uni-muenchen.de

    >