Semin Thromb Hemost 2006; 32(8): 810-813
DOI: 10.1055/s-2006-957326
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Anticoagulants and Cancer Survival

Andrea Piccioli1 , Anna Falanga2 , Paolo Prandoni1
  • 1Department of Medical and Surgical Sciences, Department of Internal Medicine, University of Padova, Italy
  • 2Division of Haematology, Department of Haematology-Oncology, Ospedali Riuniti, Bergamo, Italy
Further Information

Publication History

Publication Date:
15 December 2006 (online)

ABSTRACT

The association between cancer and activation of blood coagulation has been described since Trousseau's time. The hypercoagulable state often encountered in cancer patients not only acts as an important risk factor for thrombosis, but also may play a role in tumor progression and metastasization. An antineoplastic effect of anticoagulants in this setting has often been hypothesized. The results of recently conducted clinical trials suggest that cancer patients could have a benefit from administration of low molecular weight heparin, particularly in those with nonadvanced disease. Additional clinical trials are needed to provide an important step forward in this challenging setting.

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Andrea PiccioliM.D. 

Department of Medical and Surgical Sciences, University of Padua

Via Ospedale Civile 105, 35128 Padua, Italy

Email: andreapiccioli@libero.it

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