The fibrinolytic system was investigated in 38 patients (21 males and 17 females)
affected by type 1 diabetes mellitus (18 free from complications, 10 with retinopathy,
and 10 with autonomic neuropathy) and in 8 healthy controls. Two separate fibrinolysis-stimulating
tests were done: standardized venous occlusion and 1-desamino-8-D-arginine vasopressin
infusion. Plasma tissue plasminogen activator antigen and activity and plasma plasminogen
activator inhibitor activity were measured. All the patients were in good metabolic
control (mean HbA1c 7.4%, range 6.1-8.0%). No significant differences were observed either between the
diabetic patients and the control subjects, nor among the subgroups of diabetic patients.
The fibrinolytic system is probably not involved in type 1 diabetes mellitus.
Type 1 Diabetes Mellitus - Plasminogen Activator - Plasminogen Activator Inhibitor
- Fibrinolysis
