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Horm Metab Res 1991; 23(4): 166-167
DOI: 10.1055/s-2007-1003642
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© Georg Thieme Verlag, Stuttgart · New York

Liposome-Entrapped Calcitonin and Parathyroid Hormone Are Orally Effective in Rats

M. Fukunaga2 , M. M. Miller1 , L. J. Deftos1
  • 1Department of Medicine, University of California, San Diego, and the San Diego VA Medical Center, La Jolla, California, U. S. A.
  • 2Kawasaki Medical School, Kurashiki, Japan
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Publication History

1990

1990

Publication Date:
14 March 2008 (online)

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Orally Administered Liposomes Prepared with Egg Phosphatidylcholine and Stearylamine: Possible Destruction in Rat Intestinal WallHorm Metab Res 1992; 24(12): 597-598
DOI: 10.1055/s-2007-1003400

Summary

We have demonstrated that liposomally entrapped calcitonin (CT) and parathyroid hormone (PTH) can be orally effective in regulating blood calcium. Liposomal CT produced hypocalcemia and liposomal PTH produced hypercalcemia upon oral administration to rats. Specific liposomal formulations were necessary to affect the appropriate decrease and increase in blood calcium concentration. Future extension of these studies may lead to clinically valuable forms of liposomal-peptide preparations.

Key words

Calcitonin - Parathyroid Hormone - Liposomes - Oral Administration