Summary
In order to evaluate the effect of exogenous sex steroids on adipose tissue metabolism,
two groups of postmenopausal women were studied. In one of the groups, the effect
of 50 μg ethinyl estradiol (EE) was investigated given orally alone and in combination
with 10 mg norethisterone acetate (NET). This combination is reminiscent of an old
high dose oral contraceptive. In the other group, the effect of 3 mg 17β-estradiol
was evaluated when administered percutaneously alone and in combination with 300 mg
micronized progesterone given orally. These substances and doses were chosen to provide
a “physiological” hormonal influence.
In the femoral region 50 μg EE induced an increase in LPL activity. This elevated
LPL value was reversed with the addition of 10 mg NET. Moreover, during treatment
with 50 μg EE, a decrease in norepinephrine stimulated lipolysis was seen in the abdominal
region. The percutaneous administration of 17β-estradiol with or without micronized
progesterone, however, was inert as regards subcutaneous adipose tissue metabolism.
Our findings indicate, therefore, that EE in doses used in oral contraception might
promote lipid accumulation in the femoral adipose tissue depot.
Key words
Estrogens - Progestogens - Femoral and Abdominal Adipocytes - Lipolysis - Lipoprotein
Lipase
