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Horm Metab Res 1990; 22(8): 431-435
DOI: 10.1055/s-2007-1004940
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Increase of IGF I Binding to Erythrocyte Receptors During the TRH-Test: Correlation Between IGF I Binding and Thyroid Hormone Values

D. Murietta-Geoffroy1 , M. Donnadieu1 , P. Georges2 , J. Straczek3 , R. M. Schimpff1
  • 1INSERM U 188, Hôpital Saint Vincent de Paul, Paris
  • 2Laboratoire de Biochimie, Hôpital Saint Vincent de Paul, Paris
  • 3Laboratoire de Biochimie, Hôpital Central, Nancy, France
Further Information

Publication History

1989

1990

Publication Date:
14 March 2008 (online)

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Summary

The effects of TRH on insulin-like growth factor I receptors were investigated on erythrocytes from 7 GH-deficient children having plasma GH levels less than 10 ng/ml during two provocation tests.

Intravenous injection of synthetic TRH (0.2 mg/m2) was followed by a marked increase of IGF I binding on erythrocytes, from 3.9% ± 0.3% to 5.9% ± 0.3% (P < 0.005) after 1 hour and 7.3% ± 0.4% (P < 0.005) after 2 hours. The IGF I binding variations were due to an increase in both the receptor affinity and the number of sites.

The levels of plasma GH, IGF I, T3, T4, free T4, TSH and prolactin having been determined during the TRH test at 0, 1 hour, and 2 hours after the injection, the increase in the IGF I binding to erythrocytes at the same time correlated with the rise of thyroid hormones: triiodothyronine T3 (P < 0.001) and thyroxine T4 (P < 0.005) and not with the level of the other hormones.

These findings suggest that thyroid hormones play a role in the regulation of insulin-like growth factor I receptors.

Key words

IGF I - Receptors - TRH-Test - Thyroid Hormones