It has been shown that gossypol treatment brings about marked changes in plasma lipoproteins
of certain species causing a marked fall in total cholesterol and LDL-cholesterol
levels. Using Helena electrophoretic system the lipoprotein pattern in serum of adult
rats treated with gossypol was studied. Gossypol treatment for 1 day and 7 days continuously
did bring about changes in serum lipoprotein profile. A marked increase in VLDL-cholesterol
and fall in LDL-cholesterol was observed in rats treated with gossypol which was more
pronounced in the 7 days treated group. It did not bring about any marked change in
total cholesterol level. It did cause an increase in serum triglyceride level. Heparin
injection which brought about a fall in VLDL-cholesterol with a concomitant increase
in HDL-cholesterol in control rats did not elicit changes in gossypol-treated rats.
Thus, gossypol treatment appears to alter serum lipoprotein metabolism in rats also.
Gossypol - Adult Rats - Serum Lipoproteins - VLDL Metabolism
