Effect of Chronic Stress in the Blood Pressure in the Rat: ACTH Administration

Summary

We have studied the effect of chronic noise stress (St) and ACTH administration (Ac) affecting blood pressure and plasma corticosterone levels in male Wistar rats. Both chronic treatments elicited an increas in plasma corticosterone and blood pressure levels. The blood pressure increased from the first week of treatment period in St and Ac rats and remained high 4 weeks after the end of the stress period. However, blood pressure elevation decrease progressively during the first three weeks of post-treatment in ACTH administrated rats. The rise of blood pressure levels was due to the effect of chronic treatment. This was demonstrated by the absence of differences between the two values of blood pressure measurement with and without daily treatment in both St and Ac groups. Increased corticosterone levels decreased rapidly during the post-treatment period in St and Ac rats. The results suggest a possible relationship between the development of hypertension and the Hypothalamus-Hypophysis-adrenal (HHA) axis stimulation in rats.

Key-Words

Corticosterone - Blood Pressure - Chronic Stress - ACTH - Noise