Horm Metab Res 1988; 20: 426-429
DOI: 10.1055/s-2007-1010852
© Georg Thieme Verlag, Stuttgart · New York

An Insect Brain Peptide as a Member of Insulin Family

H. Ishizaki1 , A. Suzuki2
  • 1Biological Institute, Faculty of Science, Nagoya University, Chikusa-ku, Nagoya, Japan
  • 2Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Tokyo, Japan
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Publication History

Publication Date:
14 March 2008 (online)


Amino acid sequencing of bombyxin (previously called 4K-PTTH) isolated from the heads of the silkmoth Bombyx mori has disclosed sequence homology of this insect neuropeptide with insulin. Immunohistochemistry using an antibody against a synthetic bombyxin fragment detected 4 pairs of immunoreactive neurosecretory cells in the dorso-medial region of the Bombyx brain. The same cells were reactive to bovine insulin antibody.