Interrelation Between Glucose, Insulin, C-Peptide and 3-Hydroxybutyrate in Plasma and Amniotic Fluid in Last Trimester Diabetic Women Without Residual Betacell Function

H. Pschera; B. Persson; N. O. Lunell

doi:10.1055/s-2007-1010867

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1988; 20(8): 498-501
DOI: 10.1055/s-2007-1010867

Clinical

Interrelation Between Glucose, Insulin, C-Peptide and 3-Hydroxybutyrate in Plasma and Amniotic Fluid in Last Trimester Diabetic Women Without Residual Betacell Function

H. Pschera, B. Persson, N. O. Lunell

Department of Obstetrics and Gynecology, Huddinge University Hospital, Department of Pediatrics, St. Göran's Hospital, Karolinska Institutet, Stockholm, Sweden

Abstract

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Summary

The relationship between maternal plasma and amniotic fluid (AF) concentrations of glucose, insulin, C-peptide and 3-hydroxybutyrate (3-HB) was analysed between 45 to 140 minutes after a standardized breakfast in 8 type I diabetic women without residual betacell function and in 13 non-diabetic control women during the last trimester of gestation. AF levels of both glucose and C-peptide were slightly and AF insulin levels significantly (P < 0.05) elevated above normal in the diabetic women. 3-HB levels in plasma and in AF were significantly (P < 0.05) elevated in the diabetic group between 45 to 65 minutes after breakfast. AF insulin and glucose was significantly correlated in the diabetic group (r = 0.96, P < 0.05). During the 2 hour study period AF levels of glucose, insulin and C-peptide remained essentially unchanged in both groups of women. Changes in maternal plasma 3-HB concentrations seemed to be more rapidly reflected in AF.

Key-Words

Diabetic Pregnancy - Amniotic Fluid - Glucose - Insulin - C-Peptide - 3-HB

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