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Horm Metab Res 1988; 20(11): 687-690
DOI: 10.1055/s-2007-1010917
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

The Effect of β-Endorphin on Basal and TRH-Stimulated TSH Release in Conscious Male Rats

P. Buydens, B. Velkeniers, J. Golstein1 , E. Finné, L. Vanhaelst
  • Department of Pharmacology, Universities of Brussels (VUB-ULB), Brussels, Belgium
  • 1Institut de Recherche Interdisciplinaire (IRIBHN), Universities of Brussels (VUB-ULB), Brussels, Belgium
Further Information

Publication History

1987

1988

Publication Date:
14 March 2008 (online)

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Summary

The inhibitory effect of β-endorphin (EP) or other opioids on TSH secretion is, in contrast to their stimulating properties on PRL release, still a matter of debate.

In the present study a dose of 1 μg β-EP injected intra-cerebroventricularly (IVT) in unstressed conscious male rats, though highly effective on PRL release, did not affect basal TSH levels, nor the TRH-induced TSH secretion. The previously reported inhibition of TSH release by opioids may therefore be an effect only seen when pharmacological doses are used.

Key-Words

TSH - TRH - Endorphins