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DOI: 10.1055/s-2007-1010917
© Georg Thieme Verlag, Stuttgart · New York
The Effect of β-Endorphin on Basal and TRH-Stimulated TSH Release in Conscious Male Rats
Publikationsverlauf
1987
1988
Publikationsdatum:
14. März 2008 (online)

Summary
The inhibitory effect of β-endorphin (EP) or other opioids on TSH secretion is, in contrast to their stimulating properties on PRL release, still a matter of debate.
In the present study a dose of 1 μg β-EP injected intra-cerebroventricularly (IVT) in unstressed conscious male rats, though highly effective on PRL release, did not affect basal TSH levels, nor the TRH-induced TSH secretion. The previously reported inhibition of TSH release by opioids may therefore be an effect only seen when pharmacological doses are used.
Key-Words
TSH - TRH - Endorphins