Download PDF
Horm Metab Res 1987; 19(6): 239-241
DOI: 10.1055/s-2007-1011789
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Hepatic Regeneration Following Glucagon Treatment

K. F. Petersen, B. A. Hansen, H. E. Poulsen
  • Divisions of Hepatology and Experimental Pathology, Rigshopitalet, Copenhagen, Denmark
Further Information

Publication History

1985

1986

Publication Date:
14 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Liver regeneration was studied as a function of time after suppression of the normal glucagon response. Rats were given a daily subcutaneous injection of 20 μg zincglucagon for 14 days, whereafter a 70% hepatectomy was performed.

In the glucagon treated rats the rise in plasma glucagon concentration was diminished after hepatectomy. At intervals from 12 to 384 hours after hepatectomy, the gain in liver weight, the hepatic DNA content, and the antipyrine clearance were measured. All 3 variables were found to be significantly higher in animals with diminished glucagon response.

The results indicate that prevention of the normal increase in glucagon concentration leads to signs of increased liver regeneration after 70% hepatectomy.

Key-Words

Liver Growth - Glucagon - Liver Function

      >