The effect of a low-dose infusion of dopamine on basal circulating concentrations
of insulin, glucagon and glucose in six healthy male subjects is reported. Dopamine
(0.1 μg/kg/min) or placebo was given intravenously for 60 minutes. During infusion
of the catecholamine, circulating plasma dopamine was 3.46 ± 1 ng/ml. No change in
circulating concentrations of insulin, glucagon and glucose were seen during infusion
of dopamine when compared with placebo infusion. It is concluded that dopamine acting
at a D2 receptor is unlikely to be of physiological importance in regulation of basal pancreatic
islet cell function in man.
Insulin
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Glucagon
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Dopamine
