Summary
The plasma levels of fibronectin (Fn) have been measured in normal subjects and in
patients with thyroid diseases. The mean plasma Fn levels in 62 normal adults was
32.0±6.0 mg/dl, whereas it was elevated to 62.6±16.1 mg/dl (mean ± SD) in 25 patients
with hyperthyroidism and decreased to 19.2±8.0 mg/dl in 9 patients with hypothyroidism.
The 9 patients with simple goiter have normal values of 29.1±8.0 mg/dl. With the administration
of anti-thyroid drugs, plasma Fn levels normalized, with a time lag, in parallel with
normalization of the thyroid function. Positive correlation was obtained between Fn
levels and serum levels of triiodothyronine (T3) and thyroxine (T4). The present findings indicate that measurement of plasma Fn both in the basal state
and during treatment provides evidence of altered Fn metabolism in thyroid diseases
and serves to follow up the effect of treatment.
Key-Words
Plasma Fibronectin
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Hyperthyroidism
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Hypothyroidism
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Low T
3 Syndrome
