The effect of thyroid hormones on the reduction in resting metabolic rate by the β-blocker
propranolol has been investigated in young pigs. Oxygen consumption was measured 12
to 20 hr after the last meal in euthyroid and hypothyroid animals on a high or low
level of energy intake. The increase in resting metabolic rate in animals on the high
energy intake was reduced by propranolol in the euthyroid controls but not in those
animals made hypothyroid by methimazole. Thus at least part of the action of propranolol
to decrease diet-induced thermogenesis depends on its interaction with thyroid hormones.
Propranolol
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Thyroid
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Energy Intake
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Thermogenesis
