Thorac cardiovasc Surg 1999; 47(3): 162-165
DOI: 10.1055/s-2007-1013133
Original Cardiovascular

© Georg Thieme Verlag Stuttgart · New York

Disseminated Intravascular Coagulation in Aortic Aneurysms: Assessment of Consumption Site Using Labeled-Platelet Scintigraphy

Y. Sakakibara1 , T. Takeda2 , M. Hori1 , T. Mitsui1 , H. Ijima3
  • 1Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
  • 2Department of Radiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
  • 3Department of Surgery, Saga Prefectural Hospital Kouseikan, Saga, Japan
Further Information

Publication History

1998

Publication Date:
19 March 2008 (online)

Abstract

Background: It is known that disseminated intravascular coagulation (DIC) may occur along with aortic aneurysms. To assess the localization of the active consumption site we performed 111In-oxine labeled platelet scintigraphy in patients with chronic aortic aneurysms. Methods: Images were obtained using 111In-oxine labeled autologous platelets in 45 patients. Planar images were taken twice (at 4 and 48 hrs) after injection. A Visual inspection of the radioactivity uptake and special analysis in regions of interest were performed. Results: Thirty-five patients (78%) showed a focal accumulation of radioactivity in the aortic aneurysm. Six of 13 patients (46%) with dissecting aortic aneurysm, and 4 of 32 patients (12.5%) with true aneurysms were evaluated as negative uptake by scintigram (p<0.05). The aneurysm/heart ratio was 0.85±0.16 (mean ± SD) (4hrs) and 1.09±0.15 (48 hrs) after injection; the aneurysm/liver ratio was 0.56 ± 0.16 (4hrs) and 0.38 ± 0.09 (48 hrs); the aneurysm/ spleen ratio was 0.39 ± 0.07 (4 hrs) and 0.39 ± 0.08 (48 hrs). Conclusions: When the probability of DIC is clinically high in patients with aortic aneurysms, 111In-oxine labeled platelet scintigraphy provides useful preoperative information regarding the location of the functionally active consumption focus.