Fifty peptides and hormones from the hypophysis, hypothalamus, gastrointestinal tract
and from other origins were tested for lipolytic activity in the isolated rabbit fat
cell. Eight peptides derived from the precursor hormone proopiocortin stimulated glycerol
release while all the other peptides and hormones showed no lipolytic activity. The
most potent lipolytic peptide was alpha-MSH which also had the lowest minimal effective
dose, followed by β-lipotropin, ACTH and β-MSH. The lipolytic activity was not influenced
by the use of different collagenases or the cells from different breeds of rabbits.
Lipolysis
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Peptides and Proteins
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Rabbit Isolated Fat Cells
