Urinary Kinetics of Triiodothyronine and their Modification with Aging

J. M. Miralles-García; M. T. Mories-Alvarez; A. Reglero-Chillón; J. M. Lanao; J. J. Corrales-Hernández; L. C. García-Díez

doi:10.1055/s-2007-1013544

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1985; 17(7): 366-369
DOI: 10.1055/s-2007-1013544

Clinical

Urinary Kinetics of Triiodothyronine and their Modification with Aging

J. M. Miralles-García, M. T. Mories-Alvarez, A. Reglero-Chillón, J. M. Lanao, J. J. Corrales-Hernández, L. C. García-Díez

Servicio de Endocrinología, Cátedra de Patología General, Hospital Clínico Universitario, Salamanca, Spain
Departamento de Bioquímica, Facultad de Veterinaria, León, Spain and
Departamento de Farmacia Galénica, Facultad de Farmacia, Salamanca, Spain

Abstract

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Summary

The urinary kinetics of triiodothyronine (T₃) in healthy young and old people has been studied. The behavior of urinary excretion is similar in both age groups, expressed in our mathematical model in the cumulative kinetics as well as in the urinary rate. However, a significant decrease (P < 0.025) of renal clearance of T₃ in elderly individuals has been found. No significant differences (P > 0.05) were observed in any other kinetic parameters. The possible influence of the reduction of glomerular filtrate has been discussed as the most important pathogenic factor of the decreased renal clearance of this hormone. Possibly, modifications of the distribution volumes are also involved. Due to the limited number of persons studied, for ethical reasons, the results obtained are not definitive.

Key-Words:

Triiodothyronine - Urinary Kinetics

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