Fragments of Myelin Basic Protein Derived from Human Brain are not Mitogenic in Cultures of Human Amniotic Fluid Cells and Other Cells

G. M. Addison; P. Jackson; B. M. Snape; R. J. Thompson

doi:10.1055/s-2007-1014776

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Horm Metab Res 1984; 16(6): 311-314
DOI: 10.1055/s-2007-1014776

Fragments of Myelin Basic Protein Derived from Human Brain are not Mitogenic in Cultures of Human Amniotic Fluid Cells and Other Cells

G. M. Addison¹ , P. Jackson² , B. M. Snape¹ , R. J. Thompson²

¹Department Chemical Pathology, Royal Manchester Children's Hospital, Manchester, United Kingdom
²Department Clinical Biochemistry, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom

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Publikationsverlauf

1983

1983

Publikationsdatum:
14. März 2008 (online)

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Summary

The possible mitogenic effects of a number of preparations of the myelin basic protein (MBP) of human brain have been investigated in various cell types in culture, including human amniotic fluid cells. Intact human MBP, as well as fragments derived by BNPS-skatole and cathepsin D treatment, and isoelectric focusing fractions of human MBP, showed no mitogenic activity. These results are consistent with recent findings that the fibroblast growth factor (FGF) activity of bovine brain does not originate from MBP.

Key-Words:

Human Myelin Basic Protein - Fibroblast Growth Factor - Cell Culture