Summary
Intravenous glucose tolerance (IVGTT), basal insulin and insulin response to glucose
infusion (GIT), insulin sensitivity, and lipoprotein patterns were determined in non-obese
postcoronary subjects, 3-6 months after myocardial infarction. Twelve had decreased
and 31 normal IVGTT. The control group comprised 31 subjects with normal IVGTT, who
did not display any signs of coronary disease. The post-coronary patients were not
taking any drugs except for furosamide, which was shown not to influence insulin response
to GIT or glucose tolerance.
Decreased IVGTT in the post-coronary patients could be ascribed to decreased insulin
response and insulin resistance. These two derangements are considered as hereditary
markers in glucose intolerance and type 2 diabetes. Accordingly, our findings suggest
that glucose intolerance in subjects with myocardial infarcts has the same background.
The post-coronary patients demonstrated elevated triglycerides (TG) and cholesterol
in total serum and in very low density lipoproteins (VLDL), the lipoprotein patterns
being almost identical in post-coronary patients with or without decreased IVGTT.
No relationship was found in the control and post-coronary groups between IVGTT, basal
insulin, stimulated insulin (KI, IP), and insulin sensitivity (KG), on the one hand,
and total or VLDL TG or any other lipoprotein particle, on the other. Thus, the derangements
in glucose, insulin, and serum triglyceride metabolism were independent abnormalities
(risk factors) in these non-obese post-coronary patients.
Key-Words:
Myocardial Infarction
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Risk Factors
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Intravenous Glucose Tolerance
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Glucose Infusion Test
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Insulin Secretion
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Serum Lipoproteins
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Triglycerides
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Cholesterol
