Effects of Somatostatin, Glucagon and Insulin on Glycogen Synthesis in Isolated Rat Hepatocytes

A. J. Bone; S. I. M. Younan; J. M. Conlon

doi:10.1055/s-2007-1014837

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Horm Metab Res 1984; 16(10): 513-515
DOI: 10.1055/s-2007-1014837

Basic

Effects of Somatostatin, Glucagon and Insulin on Glycogen Synthesis in Isolated Rat Hepatocytes

A. J. Bone, S. I. M. Younan, J. M. Conlon

Departments of Clinical Biochemistry and Metabolic Medicine and Pharmacological Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom

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Publikationsverlauf

1983

1983

Publikationsdatum:
14. März 2008 (online)

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Summary

The effects of somatostatin on basal and hormonemediated rates of glycogenesis were studied in isolated rat hepatocytes. Somatostatin (1.5×10^-11 - 1.5×10^-8 M) had no effect on glycogen synthesis in the presence of 30 mM glucose and did not overcome a glucagon (1.5×10^-10 M)-induced inhibition of glycogenesis.

Key-Words:

Hepatocytes - Glycogenesis - Stomatostatin - Glucagon - Insulin