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Horm Metab Res 1984; 16(12): 674-675
DOI: 10.1055/s-2007-1014881
Short Communications

© Georg Thieme Verlag, Stuttgart · New York

Depressed Hypothalamic CRF Immunoreactivity in 15 Day Old Thiouracil-Treated Rats

L. A. Meserve
  • Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio, U.S.A.
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Publication History

1984

1984

Publication Date:
14 March 2008 (online)

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Summary

Depression of thyroid status with thiouracil has been shown to delay the response of the hypothalamus-pituitaryadrenal axis to stress in young rats. In vivo and in vitro bioassay studies have indicated that the hypothalamus is the main site of axis alteration in 15 day old animals. The present study has found a significantly depressed hypothalamic content of immunoassayable corticotropin-releasing factor (CRF) in thiouracil treated young rats.

Key-Words:

Thiouracil - Corticotropin-Releasing Factor (CRF) - Radioimmunoassay (RIA)