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Horm Metab Res 1984; 16: 102-104
DOI: 10.1055/s-2007-1014909
IV. GASTROINTESTINAL HORMONES
© Georg Thieme Verlag, Stuttgart · New York

Effects of Gastrectomy on Insulin Secretion in Rats

T. Ikeda, I. Murakami, A. Kurahashi, Y. Tokumori, A. Takeda, M. Tominaga, H. Mashiba
  • First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan
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Publication History

1983

1983

Publication Date:
14 March 2008 (online)

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Summary

To examine the relative importance of the stomach for the enteroinsular axis, the portal insulin secretion was measured in the rats with gastrectomy, after intraduodenal (I.D.) infusion of 0.5 g/kg glucose and after intravenous (I.V.) infusion of the same deal of glucose, respectively.

Portal plasma gastrin was decreased from 100 pg/ml to 5 pg/ml by gastrectomy. Blood sugar level after I.D. and I.V. infusion of glucose in the rats with gastrectomy was similar to controls. Insulin release to I.D. infusion of glucose was slightly lower at 30 minutes in the gastrectomized rats compared with controls, while insulin secretion to I.V. infusion of glucose was similar to controls.

These results suggest that endogenous gastrin has no insulinotropic effect and that the stomach has no direct effect on glucose-induced insulin release.

Key-Words:

Enteroinsular Axis - Gastrectomy - Gastrin - Insulin Secretion

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