Highly purified neutral soluble human, porcine and bovine insulin (0.075 U/kg body
weight) were administered randomly by subcutaneous injection to six normal men. Somatostatin
by continuous intravenous infusion (100 μg/h) was used to suppress endogenous insulin
secretion. The effects of the three species of insulins on plasma glucose, immunoreactive
insulin (IRI), C-peptide and intermediary metabolite concentrations were essentially
similar. The onset of hypoglycaemic action of bovine insulin was delayed compared
to human and porcine insulin due possibly to a lower receptor binding of the bovine
insulin. No local or systemic adverse reactions to the insulins were observed.
Human
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Porcine
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Bovine Insulin
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Pharmacokinetics
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Normal Subjects
