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Horm Metab Res 1983; 15(5): 218-220
DOI: 10.1055/s-2007-1018676
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© Georg Thieme Verlag, Stuttgart · New York

Fasting and Postprandial Plasma Glucagon and Glucagon-Like Immunoreactivity are Normal in Obese Pima Indians

Barbara Vasquez, M. Nagulesparan, R. H. Unger
  • Phoenix Clinical Research Section, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases, National Institutes of Health, and the Human Diabetes Study Center, Phoenix, Arizona; and The University of Texas Health Science Center at Dallas, Dallas, Texas, U.S.A.
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Publication History

1982

1982

Publication Date:
14 March 2008 (online)

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Summary

Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21-49 kg/m2) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p < 0.0001) and postprandial (r = 0.45, p < 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI > 35, n = 16) and nonobese (BMI < 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population.

Key-Words:

Glucagon - Glucagon-Like Immunoreactivity (GLI) - Enteroglucagon - Obesity - Postprandial